Table 1: Plasma lipid profile in lean and obese SHR-corpulent rats before and after three weeks of treatment with vehicle or compound 11.

PeriodLean SHR-cp
vehicle
Lean SHR-cp
compound 11
Obese SHR-cp
vehicle
Obese SHR-cp
compound 11

Total cholesterol (mg/dL)Baseline64 ± 262 ± 1122 ± 7#121 ± 8#
Week 374 ± 393 ± 3*154 ± 6#233 ± 14#*
LDL cholesterol (mg/dL)Baseline8 ± 19 ± 114 ± 1#15 ± 2#
Week 316 ± 120 ± 1*34 ± 2#
HDL cholesterol (mg/dL)Baseline21 ± 021 ± 135 ± 2#34 ± 1#
Week 323 ± 125 ± 1*42 ± 2#45 ± 2#
Triglycerides (mg/dL)Baseline60 ± 460 ± 3516 ± 79#662 ± 139#
Week 362 ± 842 ± 3*654 ± 91#
NEFA (mmol/L)Baseline1.6 ± 0.11.7 ± 0.11.4 ± 0.11.4 ± 0.1
Week 31.0 ± 0.20.7 ± 0.11.1 ± 0.11.0 ± 0.1

Data are expressed as mean ± SEM. LDL: low-density lipoprotein; HDL: high-density lipoprotein; NEFA: nonesterified fatty acid. * < 0.05 versus vehicle within genotype; # < 0.05 versus lean SHR-cp.