Table 2: Renal excretory function in lean and obese SHR-corpulent rats before and after three weeks of treatment with vehicle or compound 11.

PeriodLean SHR-cp
vehicle
Lean SHR-cp
compound 11
Obese SHR-cp
vehicle
Obese SHR-cp
compound 11

Urine flow (mL/day)Baseline18 ± 121 ± 257 ± 4#56 ± 6#
Week 324 ± 226 ± 346 ± 4# 30 ± 4*
Sodium excretion (mmol/day)Baseline2.2 ± 0.12.3 ± 0.23.5 ± 0.2#3.1 ± 0.2#
Week 32.4 ± 0.12.0 ± 0.23.2 ± 0.3#2.7 ± 0.3#
Potassium excretion (mmol/day)Baseline5.0 ± 0.35.1 ± 0.38.4 ± 0.3# 8.3 ± 0.3#
Week 35.6 ± 0.24.8 ± 0.58.0 ± 0.6#
Chloride excretion (mmol/day)Baseline3.7 ± 0.23.7 ± 0.35.8 ± 0.2#5.3 ± 0.3#
Week 33.7 ± 0.13.1 ± 0.35.3 ± 0.5#4.6 ± 0.2#
Glucose excretion (mg/day)Baseline7 ± 29 ± 13568 ± 391#3638 ± 538#
Week 36 ± 24 ± 11148 ± 220#
Creatinine clearance (L/day)Baseline6.00 ± 0.565.86 ± 0.205.47 ± 0.355.14 ± 0.20
Week 36.28 ± 0.605.08 ± 0.775.95 ± 1.365.00 ± 0.23
Microalbumin excretion (mg/day)Baseline 2 ± 0 1 ± 049 ± 15#50 ± 22#
Week 35 ± 1 10 ± 8 85 ± 28#77 ± 28#

Data are expressed as mean ± SEM. * < 0.05 versus obese SHR-cp vehicle; # < 0.05 versus lean SHR-cp.