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Figure 1: Potential applications of human iPSCs. The iPSCs technology can be potentially used in disease modeling, drug discovery, gene therapy, and cell replacement therapy. Differentiated cells are acquired by biopsies from human tissues and in vitro cultured under stem cell transcription factors, such as SOX2 (SRY-box containing gene 2), c-Myc (v-myc avian myelocytomatosis viral oncogene homolog), OCT4 (octamer-binding transcription factor 3), and KlF4 (Kruppel-like factor 4). After induction of pluripotency phenotype, the cells, known as iPSCs, can be utilized to redifferentiation in specific disease, to drug screening, or to have the genomic defect corrected, and then the iPSCs become able to be reutilized as health cells in the regenerative therapies.