Table 3: Summary of cancer-derived hiPSCs.

Type of cancer (hematologic malignancies and solid tumors)Aim of studyMethod of generation of the cancer hiPSCsReferences

Myeloproliferative disorder (MPD) with JAK2-V617F somatic mutationTo generate iPS cells to provide a renewable cell source and a prospective hematopoiesis model for investigating MPD pathogenesisFrozen peripheral blood CD34+ cells from 2 patients with MPD/retroviral transductionYe et al., 2009 [55]
Chronic myeloid leukemia (CML)To address whether human cancer cells can be reprogrammed into iPSCsCell line, KBM7, derived from blast crisis stage of CML/retroviral transductionCarette et al., 2010 [56]
Chronic myeloid leukemia (CML)To eliminate the genomic integration and background transgene expression, toward advancing iPSCs technology for the modeling of blood diseasesBone marrow mononuclear cells from a patient with CML (chronic phase)/episomal vectorsHu et al., 2011 [57]
Chronic myeloid leukemia (CML)To investigate CML pathogenesis on the basis of patient-derived samplesTwo patients samples of CML (chronic phase) bone marrow cells, retrovirus and Sendai virus systemKumano et al., 2012 [19]
Juvenile myelomonocytic leukemia (JMML)To explore the pathophysiology and treatment of JMMLTwo pediatric patient’s samples from bone marrow or peripheral blood/lentivirus Gandre-Babbe et al., 2013 [61]
Gastrointestinal cancerTo study new cancer therapies via reprogramming approaches in cancer cellsGastrointestinal cell lines of cancers from esophageal, stomach, colorectal, pancreas, and liver and bile ducts/lentiviral and retroviralMiyoshi et al., 2010 [58]
Gastrointestinal cancerGenerate a human cell model of early pancreatic cancer and disease progression for biomarkers detection for useful diagnosisTissue from the center of pancreatic ductal adenocarcinoma (PDAC) sample of patient/lentivirus systemKim et al., 2013 [59]