430791.fig.002a
(a)
430791.fig.002b
(b)
430791.fig.002c
(c)
430791.fig.002d
(d)
Figure 2: Comparison of SDH and MAO activities, MPTP opening, and decreases in A520 for the two groups. (a) Comparison of SDH activities in cardiac mitochondria from fasudil-treated, untreated diabetic, and control rats revealed statistically significant differences. SDH activities in cardiac mitochondria from fasudil-treated group were marked higher than that of untreated diabetic group ( ). (b) Comparison of MAO activities in cardiac mitochondria from fasudil-treated, untreated diabetic, and control rats revealed statistically significant differences. MAO activities in cardiac mitochondria from fasudil-treated group were significantly higher than that of untreated diabetic group ( ). (c) Effects of fasudil on MPTP opening (A520: absorbance at 520 nm). The trace represented the mean of A520 from three groups. The top trace represented cardiac mitochondria from SD control rats, the middle trace showed the absorbance in mitochondria from diabetic rats treated with fasudil, and lower traces showed the absorbance in mitochondria from untreated diabetic rats. (d) Comparison of decreases in A520 for the three groups. The decreases in A520 were significantly lower in diabetic rats treated with fasudil compared to untreated rats ( ).