The Protective Effect of Fasudil on the Structure and Function of Cardiac Mitochondria from Rats with Type 2 Diabetes Induced by Streptozotocin with a High-Fat Diet Is Mediated by the Attenuation of Oxidative Stress
Table 1
Effects of fasudil on body weight, heart weight, blood pressure, blood glucose, serum insulin, glycated hemoglobin, and lipid profiles in diabetic rats either treated with or without fasudil.
Fasudil-treated diabetic group ()
Untreated diabetic group ()
Control group ()
Start weight (g)
191 ± 7
190 ± 8
192 ± 7
End weight (g)
465 ± 9#
442 ± 10*
465 ± 10
Heart weight (g)
1.72 ± 0.11
1.68 ± 0.09*
1.78 ± 0.06
Mean blood pressure (kpa)
8.21 ± 1.21
9.44 ± 1.59
8.43 ± 1.25
Fasting blood glucose (mmol/L)
20.0 ± 2.6*
19.9 ± 2.4*
6.1 ± 0.2
Serum insulin (ng/mL)
6.17 ± 0.99*
5.97 ± 1.00*
4.78 ± 0.67
Glycated hemoglobin (%)
13.4 ± 1.7*
12.5 ± 1.8*
4.9 ± 0.4
Total cholesterol (mmol/L)
1.41 ± 0.15*
1.40 ± 0.13*
0.95 ± 0.12
Triglyceride (mmol/L)
0.63 ± 0.10
0.61 ± 0.08
0.55 ± 0.06
Free fatty acids (mmol/L)
0.33 ± 0.06
0.40 ± 0.18*
0.28 ± 0.07
Data are presented as the mean ± SD.
*
versus control group.
# versus untreated diabetic group.