Ulinastatin Reduces Cancer Recurrence after Resection of Hepatic Metastases from Colon Cancer by Inhibiting MMP-9 Activation via the Antifibrinolytic Pathway

Figure 1

Transwell in vitro invasion assay detects the effect of ulinastatin on the invasive ability of colon cancer cells. (a) Control group without reagents; (b) low-dose ulinastatin (L-UTI) group, 800 U/mL ulinastatin; (c) high-dose ulinastatin (H-UTI) group, 8000 U/mL ulinastatin; (d) IL-1α (10 ng/mL) + plasminogen group (10 μg/mL); (e) IL-1α (10 ng/mL) + plasminogen (10 μg/mL) + L-UTI group (800 U/mL); (f) IL-1α (10 ng/mL) + plasminogen (10 μg/mL) + L-UTI group (8000 U/mL); (g) GM6001 group (0.8 nmol/L).

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