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BioMed Research International
Volume 2013 (2013), Article ID 437950, 10 pages
http://dx.doi.org/10.1155/2013/437950
Research Article

Ulinastatin Reduces Cancer Recurrence after Resection of Hepatic Metastases from Colon Cancer by Inhibiting MMP-9 Activation via the Antifibrinolytic Pathway

1Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical College, 1 Panfu Road, Yuexiu District, Guangzhou 510180, China
2Experimental Medical Research Center, Guangzhou Medical College, 195 Dongfengxi Road, Yuexiu District, Guangzhou 510182, China

Received 28 January 2013; Revised 26 March 2013; Accepted 2 April 2013

Academic Editor: Paul Higgins

Copyright © 2013 Bo Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. S. Hughes, R. Simon, S. Songhorabodi, et al., “Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence,” Surgery, vol. 100, no. 2, pp. 278–284, 1986. View at Scopus
  2. W. R. Jarnagin, “Management of small hepatocellular carcinoma: a review of transplantation, resection, and ablation,” Annals of Surgical Oncology, vol. 17, no. 5, pp. 1226–1233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Xu, Y. Wei, Y. Zhong et al., “Hepatectomy for liver metastasis of colorectal cancer,” International Journal of Colorectal Disease, vol. 24, no. 4, pp. 419–425, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Talvinen, J. Tuikkala, J. Grönroos et al., “Biochemical and clinical approaches in evaluating the prognosis of colon cancer,” Anticancer Research, vol. 26, no. 6C, pp. 4745–4751, 2006. View at Scopus
  5. Y. J. Chua and D. Cunningham, “Neoadjuvant treatment of unresectable liver metastases from colorectal cancer,” Clinical Colorectal Cancer, vol. 5, no. 6, pp. 405–412, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Asaga, K. Suzuki, M. Umeda, Y. Sugimasa, S. Takemiya, and T. Okamoto, “The enhancement of tumor growth after partial hepatectomy and the effect of sera obtained from hepatectomized rats on tumor cell growth,” Japanese Journal of Surgery, vol. 21, no. 6, pp. 669–675, 1991. View at Scopus
  7. M. Gutman, R. K. Singh, J. E. Price, D. Fan, and I. J. Fidler, “Accelerated growth of human colon cancer cells in nude mice undergoing liver regeneration,” Invasion and Metastasis, vol. 14, no. 1–6, pp. 362–371, 1994. View at Scopus
  8. J. Mizutani, T. Hiraoka, R. Yamashita, and Y. Miyauchi, “Promotion of hepatic metastases by liver resection in the rat,” British Journal of Cancer, vol. 65, no. 6, pp. 794–797, 1992. View at Scopus
  9. N. Harun, M. Nikfarjam, V. Muralidharan, and C. Christophi, “Liver regeneration stimulates tumor metastases,” Journal of Surgical Research, vol. 138, no. 2, pp. 284–290, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Xu, W. S. Cai, H. Q. Xiao et al., “Influence of liver regeneration after partial hepatectomy on the development of liver metastasis of colon cancer in rats,” Zhonghua Wai Ke Za Zhi, vol. 47, no. 5, pp. 369–372, 2009. View at Scopus
  11. M. F. Leeman, S. Curran, and G. I. Murray, “New insights into the roles of matrix metalloproteinases in colorectal cancer development and progression,” Journal of Pathology, vol. 201, no. 4, pp. 528–534, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Matsuyama, S. Takao, and T. Aikou, “Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas,” Journal of Surgical Oncology, vol. 80, no. 2, pp. 105–110, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Zucker, “A critical appraisal of the role of proteolytic enzymes in cancer invasion: emphasis on tumor surface proteinases,” Cancer Investigation, vol. 6, no. 2, pp. 219–231, 1988. View at Scopus
  14. S. Zucker, J. Cao, and W. T. Chen, “Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment,” Oncogene, vol. 19, no. 56, pp. 6642–6650, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Dormn, S. Cseh, I. Hajd et al., “Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility,” Drugs, vol. 70, no. 8, pp. 949–964, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Mignatti and D. B. Rifkin, “Biology and biochemistry of proteinases in tumor invasion,” Physiological Reviews, vol. 73, no. 1, pp. 161–195, 1993. View at Scopus
  17. N. M. Hogan, R. M. Dwyer, M. R. Joyce, and M. J. Kerin, “Mesenchymal stem cells in the colorectal tumor microenvironment: recent progress and implications,” International Journal of Cancer, vol. 131, no. 1, pp. 1–7, 2012. View at Publisher · View at Google Scholar
  18. M. J. Pugia and J. A. Lott, “Pathophysiology and diagnostic value of urinary trypsin inhibitors,” Clinical Chemistry and Laboratory Medicine, vol. 43, no. 1, pp. 1–16, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Kobayashi, M. Suzuki, Y. Tanaka, N. Kanayama, and T. Terao, “A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-β1 signaling cascade,” Journal of Biological Chemistry, vol. 278, no. 10, pp. 7790–7799, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Kobayashi, T. Yagyu, K. Inagaki et al., “Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer,” Cancer, vol. 100, no. 4, pp. 869–877, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Suzuki, H. Kobayashi, Y. Tanaka et al., “Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin,” International Journal of Cancer, vol. 104, no. 3, pp. 289–302, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Yoshioka, Y. Tsuchiya, Y. Aozuka et al., “Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells,” Anticancer Research, vol. 25, no. 2A, pp. 815–820, 2005. View at Scopus
  23. K. H. Tsui, P. L. Chang, T. H. Feng, L. C. Chung, S. Y. Hsu, and H. H. Juang, “Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells,” Anticancer Research, vol. 28, no. 4A, pp. 1977–1983, 2008. View at Scopus
  24. M. Nikfarjam, V. Muralidharan, and C. Christophi, “Altered growth patterns of colorectal liver metastases after thermal ablation,” Surgery, vol. 139, no. 1, pp. 73–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Shimizu, Y. Saitoh, and H. Itoh, “Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues,” Human Pathology, vol. 21, no. 6, pp. 607–612, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. F. S. Collins, “Reengineering translational science: the time is right,” Science Translational Medicine, vol. 3, no. 90, p. 90cm17, 2011. View at Publisher · View at Google Scholar
  27. T. Tsujino, Y. Komatsu, H. Isayama et al., “Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial,” Clinical Gastroenterology and Hepatology, vol. 3, no. 4, pp. 376–383, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. W. A. Hoogerwerf, “Pharmacological management of pancreatitis,” Current Opinion in Pharmacology, vol. 5, no. 6, pp. 578–582, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Aihara, M. Shiraishi, S. Hiroyasu et al., “Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating TNF-α in the liver,” Transplantation Proceedings, vol. 30, no. 7, pp. 3732–3734, 1998. View at Scopus
  30. H. Nakahama, K. Obata, and M. Sugita, “Ulinastatin ameliorates acute ischemic renal injury in rats,” Renal Failure, vol. 18, no. 6, pp. 893–898, 1996. View at Scopus
  31. Z. L. Cao, Y. Okazaki, K. Naito, T. Ueno, M. Natsuaki, and T. Itoh, “Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart,” Annals of Thoracic Surgery, vol. 69, no. 4, pp. 1121–1126, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. O. A. R. Binns, N. F. DeLima, S. A. Buchanan et al., “Neutrophil endopeptidase inhibitor improves pulmonary function during reperfusion after eighteen-hour preservation,” Journal of Thoracic and Cardiovascular Surgery, vol. 112, no. 3, pp. 607–613, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Okuhama, M. Shiraishi, T. Higa et al., “Protective effects of ulinastatin against ischemia-reperfusion injury,” Journal of Surgical Research, vol. 82, no. 1, pp. 34–42, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Nakanishi, S. Takeda, A. Sakamoto, and A. Kitamura, “Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction,” Critical Care Medicine, vol. 34, no. 5, pp. 1351–1357, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Nishiyama, T. Yokoyama, and K. Yamashita, “Effects of a protease inhibitor, ulinastatin, on coagulation and fibrinolysis in abdominal surgery,” Journal of Anesthesia, vol. 20, no. 3, pp. 179–182, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Kurosawa, N. Kanaya, N. Fujimura et al., “Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy,” Journal of Clinical Anesthesia, vol. 18, no. 1, pp. 18–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Yano, S. Anraku, R. Nakayama, and K. Ushijima, “Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats,” Anesthesiology, vol. 98, no. 2, pp. 465–473, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Kobayashi, M. Suzuki, N. Kanayama, T. Nishida, M. Takigawa, and T. Terao, “Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade,” European Journal of Biochemistry, vol. 269, no. 16, pp. 3945–3957, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Masson, M. Daveau, M. Hiron et al., “Differential regenerative response and expression of growth factors following hepatectomy of variable extent in rats,” Liver, vol. 19, no. 4, pp. 312–317, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. W. Jiang, S. Hiscox, K. Matsumoto, and T. Nakamura, “Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer,” Critical Reviews in Oncology/Hematology, vol. 29, no. 3, pp. 209–248, 1999. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Lukomska, J. Dluzniewska, J. Polanski, and L. Zajac, “Expression of growth factors in colorectal carcinoma liver metastatic patients after partial hepatectomy: implications for a functional role in cell proliferation during liver regeneration,” Comparative Hepatology, vol. 3, supplement 1, p. S52, 2004. View at Publisher · View at Google Scholar
  42. S. S. Yoon, S. H. Kim, M. Gonen et al., “Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases,” Annals of Surgical Oncology, vol. 13, no. 3, pp. 353–362, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Mazzieri, L. Masiero, L. Zanetta et al., “Control of type IV collagenase activity by the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants,” The EMBO Journal, vol. 16, no. 9, pp. 2319–2332, 1997. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Inuzuka, Y. Ogata, H. Nagase, and K. Shirouzu, “Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma,” Journal of Surgical Research, vol. 93, no. 2, pp. 211–218, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. A. H. Mekkawy, D. L. Morris, and M. H. Pourgholami, “Urokinase plasminogen activator system as a potential target for cancer therapy,” Future Oncology, vol. 5, no. 9, pp. 1487–1499, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. M. D. Sternlicht and Z. Werb, “How matrix metalloproteinases regulate cell behavior,” Annual Review of Cell and Developmental Biology, vol. 17, pp. 463–516, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Nobuoka, T. Mizuguchi, H. Oshima et al., “Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice,” Liver International, vol. 29, no. 7, pp. 979–987, 2009. View at Publisher · View at Google Scholar · View at Scopus