Research Article

Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications

Table 3

Association between CISH signal patterns and grading of cervical lesions ( ).

CISH result Number of cases (%)Total
CIN1
CIN2CIN3SCC

Invalid
2 (8)1 (6.3)003 (4.8)
Negative
9 (36)1 (6.3)4 (19)014 (22.2)
Diffuse
9 (36)1 (6.3)0 010 (15.9)
Diffuse-punctated
5 (20)11 (68.7)11 (52.4)027 (42.8)
Punctated
02 (12.4)6 (28.6)1 (100)9 (14.3)
Total
25 (39.7)16 (25.4)21 (33.3)1 (1.6)63