Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">p16 interobservers agreement</td><td align="center" colspan="5">Histological diagnosis</td></tr><tr class="thead"><td align="center">CIN1 (%)</td><td align="center">CIN2 (%)</td><td align="center">CIN3 (%)</td><td align="center">SCC (%)</td><td align="center">Total</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td align="left">Positive</td><td align="center">8 (32)</td><td align="center">11 (68.8)</td><td align="center">12 (57.1)</td><td align="center">1 (100)</td><td align="center"><b>32 (50.8)</b></td></tr><tr><td align="left">Negative</td><td align="center">17 (68)</td><td align="center">5 (31.2)</td><td align="center">9 (42.9)</td><td align="center">0</td><td align="center"><b>31 (49.2)</b></td></tr><tr><td align="left">Total</td><td align="center"><b>25 (39.7)</b></td><td align="center"><b>16 (25.4)</b></td><td align="center"><b>21 (33.3)</b></td><td align="center"><b>1 (1.6)</b></td><td align="center"><b>63</b></td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

p16 immunostaining: interobserver agreement within histological categories of cervical lesions.

BioMed Research International

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Table 4

Table 4: Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications 

Table 4 | Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications 