Parasitic Infections: A Role for C-Type Lectins Receptors

Table 1

Summary of structural and functional properties of the lectin family receptors.

Group	Molecules structure	Family members	Ligands	Expression	Function	Reference
		MR	Mannose, fucose, and; N-acetylglucosamine	MoPh, retina DCs, LCs, Fbls, and kidney	Pathogen recognition, antigen presentation, clearance of endogenous cytopathic molecules, and regulation of circulating hormones	[3–14]
		DC-SIGN	Mannose, ICAM-3	Mesangial cells and CMs, MØ, and DCs	Pathogen recognition, antigen presentation, cell migration, and DC-T-cell interactions
C-type	Type-I Type-II; (Tm)	SIGNR-1	Zymosan, mannans, and dextran	iDCs spleen MZ, lymph node, and pMØ	Clearance of blood borne antigens
		Dentin1	β-glucans	DCs, neutrophils, and splenic T cells	Antifungal host defense, induction of TNF-α, and regulation of T-cell proliferation
		Dectin2	α-mannans	MØ, DCs	Impairment of UV-induced tolerance
		mMGL1	Gal	MØ, DCs	Internalization and antigen presentation, bind to CD45 to inhibit T cells
		mMGL2	Sructure Le^x	MØ, DCs	Anti-inflammatory response
		L-SIGN	Structure Le^(a,b,y)	Liver sinusoidal endothelial cells	Antigen receptor
P-type	Type-I; (Tm)	CD-MPR; CI-MPR	Man-P-GlcNAc; Man-6-P	Lysosomal hydrolases	Transport Man-6-P containing acid hydrolases from the Golgi to endosomal/lysosomal compartments	[15–17]
F-type		AAA; MsaFBP32	Fucose	Liver and kidney	Modulation of cell functions	[18–22]
I-type	Type-I; (Tm)	Siglec-1; Siglec-2; Siglec-4; Siglec-15	Sialic acids with N- and O-linked glycosylations	Myeloid and lymphoid cells	Regulation of cell signaling from leucocytes	[23, 24]
		Siglec-3; 10 members humans (3, 5, 6, 7, 8, 9, 10, 11, 14, 16); Rodents Siglec-3, E, F, G, H			Endocytic receptors

Abbreviations: Tm: transmenbrane; MØ: macrophages; pMØ: peritoneal macrophages; Dcs: dendritic cells; iDCs: immature dendritic cells; MoPh: mononuclear phagocytes; Fbls: fibroblasts; LCs: langerhans cells; CMs: cardiomyocytes; Le^x: Lewis x, a, b, and y structures; Gal: galactose; MR: mannose receptor; DC-SIGN: dendritic cell-specific ICAM-3-grabbing nonintegrin; SIGNR-1: SIGN-related 1; homologe DC-SIGN; mMGL: macrophage galactose type c-lectin; L-SIGN: liver/lymph node-specific ICAM-3 grabbing nonintegrin; CD-MPR: cation-dependent mannose 6-phosphate receptor; CI-MPR: cation-independent mannose 6-phosphate receptor; Man-6-P: mannose 6-phosphate; Man-P-GlcNAc: mannose 6-phisphate N-acetylglucosamine ester; AAA: Anguilla anguilla agglutinin; MsaFBP32: F-lectin present in striped bass (Morone saxatilis).