Table 1: Summary of structural and functional properties of the lectin family receptors.

GroupMolecules structureFamily membersLigandsExpressionFunctionReference

MR Mannose, fucose, and
N-acetylglucosamine
MoPh, retina DCs, LCs, Fbls, and kidneyPathogen recognition, antigen presentation, clearance of endogenous cytopathic molecules, and regulation of circulating hormones [314]
DC-SIGN Mannose, ICAM-3 Mesangial cells and CMs, MØ, and DCsPathogen recognition, antigen presentation, cell migration, and DC-T-cell interactions
C-typeType-I Type-II
(Tm)
SIGNR-1 Zymosan, mannans, and dextraniDCs spleen MZ, lymph node, and pMØClearance of blood borne antigens
Dentin1 β-glucansDCs, neutrophils, and splenic T cellsAntifungal host defense, induction of TNF-α, and regulation of T-cell proliferation
Dectin2 α-mannansMØ, DCsImpairment of UV-induced tolerance
mMGL1 GalMØ, DCsInternalization and antigen presentation, bind to CD45 to inhibit T cells
mMGL2 Sructure LexMØ, DCs Anti-inflammatory response
L-SIGNStructure Le(a,b,y)Liver sinusoidal endothelial cellsAntigen receptor

P-typeType-I
(Tm)
CD-MPR
CI-MPR
Man-P-GlcNAc
Man-6-P
Lysosomal hydrolasesTransport Man-6-P containing acid hydrolases from the Golgi to endosomal/lysosomal compartments[1517]

F-typeAAA
MsaFBP32
FucoseLiver and kidneyModulation of cell functions[1822]

I-typeType-I
(Tm)
Siglec-1
Siglec-2
Siglec-4
Siglec-15
Sialic acids with N- and O-linked glycosylationsMyeloid and lymphoid cellsRegulation of cell signaling from leucocytes[23, 24]
Siglec-3
10 members humans (3, 5, 6, 7, 8, 9, 10, 11, 14, 16)
Rodents Siglec-3, E, F, G, H
Endocytic receptors

Abbreviations: Tm: transmenbrane; MØ: macrophages; pMØ: peritoneal macrophages; Dcs: dendritic cells; iDCs: immature dendritic cells; MoPh: mononuclear phagocytes; Fbls: fibroblasts; LCs: langerhans cells; CMs: cardiomyocytes; Lex: Lewis x, a, b, and y structures; Gal: galactose; MR: mannose receptor; DC-SIGN: dendritic cell-specific ICAM-3-grabbing nonintegrin; SIGNR-1: SIGN-related 1; homologe DC-SIGN; mMGL: macrophage galactose type c-lectin; L-SIGN: liver/lymph node-specific ICAM-3 grabbing nonintegrin; CD-MPR: cation-dependent mannose 6-phosphate receptor; CI-MPR: cation-independent mannose 6-phosphate receptor; Man-6-P: mannose 6-phosphate; Man-P-GlcNAc: mannose 6-phisphate N-acetylglucosamine ester; AAA: Anguilla anguilla agglutinin; MsaFBP32: F-lectin present in striped bass (Morone saxatilis).