Parasitic Infections: A Role for C-Type Lectins Receptors

Table 2

C-type lectins in parasitic infection.

Parasite	Receptor	Model	In vivo/in vitro	Role	Reference
Protozoo
L. donovani	MR	BALB/c mice	in vivo/ in vitro	Uptake of mannose containing glycoconjugates	[48]
	MR	Swiss albino mice	in vitro	Binding promastigotes	[36]
	MR	hmDMØ	in vitro	Attachment and ingestion promastigotes	[49]
L. amazonensis	MR	Skin Fbls	in vitro	Uptake of mannosylated ligands	[6]
L. major	MR	BMDMs; MR-KO mice	in vivo	Recognizes mannose residues on the surface Leishmania, but it’s not essential for host defense	[45]
L. pifanoi	DC-SIGN	MDDCs; cell line K562	in vitro	Binding and internalization of amastigotes	[50]
L. pifanoi; L. infantum	DC-SIGN	IMDDCs; cell lineK562	in vitro	Receptor for promastigotes and amastigote infective stages from both visceral and cutaneous leishmaniasis	[51]
T. cruzi; Tulahuen strain	MR	BALB/c mice; Cell line J774 (MØ)	in vivo/in vitro	Bind to Cz, increasing MR recycling which leads to arginase activity	[46]
Y and DM strains	MR	CM and MØ	in vitro	Adhesion and uptake of parasites	[52]
T. brucei	MGL	C57BL/6 mice; BALB/c mice	in vivo	Marker of aaMØ	[53]
Nematodes
T. muris	MR	C57BL/6 MR-KO mice	in vivo/in vitro	Recognized components E/S of parasites	[47]
Trematodes
S. mansoni	MGL	Cell lines SW948,; SKBR3, ZR75-1; CHO, BLM, FM3.29; FM6, SK23mel	in vitro	Recognized LDN and LDNF glycans	[54]
	MGL	Human DCs	in vitro	Internalization of glycolipids of SEA	[55]
	DC-SIGN	Human DCs	in vitro	Adhesion to glycolipids of SEA	[7]
	DC-SIGN	Human DCs	in vitro	Recognize glycans of SEA	[56]
	L-SIGN	Cell line K562	in vitro	Binds to structures Le^a,b,y of SEA	[8]
	L-SING	Cell line K562	in vitro	Binds and internalization of SEA	[57]
	SIGNR1	BALB/c WT; or SIGNR1-KO	in vivo/in vitro	Recognize antigens of AWA and SEA	[9]
	Dectin-2	C57BL/6	in vivo/in vitro	Binds SEA component	[58]
	MR	C57BL/6 WT or; MR-KO	in vivo/in vitro	Internalization E/S material by schistosome larvae	[59]
Cestodes; T. crassiceps	MGL; DC-SIGN	Human DCs	in vitro	TcES positively modulated the expression of MGL but negatively modulated DC-SIGN	[60]

Abbreviations: MR: mannose receptor; DC-SIGN: dendritic cell-specific ICAM-3 grabbing nonintegrin; SIGNR-1: SIGN-related 1; homologe DC-SIGN; mMGL: macrophage galactose type c-lectin; L-SIGN: liver/lymph node-specific ICAM-3 grabbing nonintegrin; Fbls: fibroblasts; BMDMs: bone marrow-derived macrophages; MDDCs: monocyte-derived dendritic cells; IMDDCs: immature monocyte-derived DCs; MØ: macrophages; CM: cardiomyocyte; Cz: cruzipaina; E/S: excretory/secretory; LDN: [GalNAcβ1–4GlcNAc-R]; LDNF: [GalNAcβ1–4(Fucα1–3)GluNAc-R]; SEA: soluble egg antigens; Le: structures of Lewis; AWA: adult worm antigen; TcES: Taenia crassiceps excreted-secreted antigens.