Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification
Table 3
Comparison of interaction categories between typical and atypical SCZ drugs using ATC first-level classification.
ATC first-level classification (ATC code)
Number of typical drug interactions (%a)
Number of atypical drug interactions (%b)
Fisher's exact test -value
Alimentary tract and metabolism (A)
74 (11.60)
5 (1.94)
Nervous system (N)
216 (33.86)
119 (46.12)
0.0008
Antiinfectives for systemic use (J)
66 (10.34)
46 (17.83)
0.0035
Sensory organs (S)
51 (7.99)
12 (4.65)
0.0839
Various (V)
8 (1.25)
0 (0)
0.1136
Respiratory system (R)
35 (5.49)
8 (3.10)
0.1668
Antineoplastic and immunomodulating agents (L)
37 (5.80)
21 (8.14)
0.2297
Antiparasitic products, insecticides, and repellents (P)
36 (5.64)
10 (3.88)
0.3191
Cardiovascular system (C)
68 (10.66)
23 (8.91)
0.4662
Musculoskeletal system (M)
3 (0.47)
0 (0)
0.5612
Genitourinary system and sex hormones (G)
19 (2.98)
6 (2.33)
0.6618
Dermatologicals (D)
21 (3.29)
7 (2.71)
0.8325
Systemic hormonal preparations, excluding sex hormones and insulins (H)
3 (0.47)
1 (0.39)
1.0000
Blood and blood forming organs (B)
1 (0.16)
0 (0)
1.0000
The percentage was calculated by the number of interactions with SCZ atypical in each category divided by all the numbers of interactions with SCZ atypical drugs.
bThe percentage was calculated by the number of interactions with SCZ typical in each category divided by all the numbers of interactions with SCZ typical drugs.
