Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification

Table 4

Comparison of interaction categories between SCZ typical and atypical drugs using ATC third-level classification.

ATC third-level classification (ATC code)	Number of typical drug interactions (%^a)	Number of atypical drug interactions (%^b)	Fisher's exact test 𝑃-value
Antiepileptics (N03A)	3 (0.47)	21 (3.30)	1.95×10^−8
Anxiolytics (N05B)	1 (0.16)	11 (1.73)	2.91×10^−5
Hypnotics and sedatives (N05C)	3 (0.47)	10 (1.57)	1.13×10^−3
Psychostimulants, agents used for ADHD and nootropics (N06B)	28 (4.40)	2 (0.31)	0.0012
Direct acting antivirals (J05A)	13 (2.04)	17 (2.67)	0.0051
Quinolone antibacterials (J01M)	18 (2.83)	1 (0.16)	0.0107
Drugs for treatment of tuberculosis (J04A)	2 (0.31)	6 (0.94)	0.0161

aThe percentage was calculated by the number of interactions with SCZ atypical in each category divided by all the numbers of interactions with SCZ atypical drugs.
^bThe percentage was calculated by the number of interactions with SCZ typical in each category divided by all the numbers of interactions with SCZ typical drugs.