Effects of Tamarindus indica Fruit Pulp Extract on Abundance of HepG2 Cell Lysate Proteins and Their Possible Consequential Impact on Metabolism and Inflammation

Figure 2

IPA graphical representation of the molecular relationships between HepG2 secreted and cytosolic proteins after treatment. The network is displayed graphically as nodes (proteins) and edges (the biological relationships between the nodes). Nodes in red indicate up-regulated proteins while those in green represent down-regulated proteins. Nodes without colors indicate unaltered expression. Various shapes of the nodes represent functional class of the proteins. Edges are displayed with various labels that describe the nature of the relationship between the nodes. Transthyretin, TTR; thyroglobulin, TG; interleukin-1 beta, IL1B; tumour necrosis factor, TNF; apolipoprotein A-1, APOA1; apolipoprotein C-1, APOC1; lecithin cholesterol acyltransferase, LCAT; endothelial lipase, LIPG; haptoglobin, HP; phospholipase A2, PLA2G2A; cholesterylester transfer protein, CETP; ATP-binding cassette transporter sub-family C member 9, ABCC9; ATP-sensitive inward rectifier potassium channel 11, KCNJ11; ectonucleotide pyrophosphatase/phosphodiesterase family member 1, ENPP1; amyloid precursor protein, APP; glyceraldehyde-3-phosphate dehydrogenase, GAPDH; alpha enolase, ENO1; adenylate kinase, AK1; ubiquinol-cytochrome-c reductase complex core protein 2, UQCRC2; xanthine dehydrogenase, XDH; cystathionine beta-synthase, CBS; methionine adenosyltransferase I, alpha, MAT1A; rab GDP dissociation inhibitor beta, GDI2; NLR (nucleotide-binding domain and leucine rich repeat containing family) family, pyrin domain containing 3, NLRP3; Vacuolar ATP synthase subunit E, ATP6V1E1; elongation factor Tu, TUFM; prohibitin, PHB; choline-phosphate cytidylyltransferase A, PCYT1A; uridine 5′-monophosphate synthase, UMPS; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10, NDUFA10; NADH dehydrogenase (ubiquinone) flavoprotein 1, NDUFV1; mediator of RNA polymerase III transcription subunit 30, MED30; transcription factor E2F1, E2F1; suppressor of G2 allele of SKP1 homolog, SUGT1.