Natural Killer Dendritic Cells Enhance Immune Responses Elicited by α-Galactosylceramide-Stimulated Natural Killer T Cells
Figure 6
NKDCs mediate the anti-metastatic effect following α-GC stimulation. B16 tumor cells (1 × 105/mouse) and 1.5 × 106 DCs (either total DCs or NKDC-depleted DCs) from WT mice were i.v. transferred to DT-treated CD11c-DTR Tg mice. One hour later, α-GC was administered i.p. into both groups of mice. On day 14 after injection, mice were sacrificed, and the number of metastatic tumor nodules in the lung was counted. (a) Representative photos of lung samples from each group are shown. (b) The mean numbers of metastatic melanomas in the lung are shown. Representative results from two independent experiments are shown. The mean values ± SD are shown ( for each experiment, ).
