Prolonged Delivery of Ciprofloxacin and Diclofenac Sodium from a Polymeric Fibre Device for the Treatment of Peridontal Disease

Table 4

MIC results for ciprofloxacin/diclofenac-loaded fibres from dissolution samples in PBS pH 4.0 and 6.8 over 10 days.

Dissolution samples	PBS pH 4.0			PBS pH 6.8
	E. coli	E. faecalis	S. mutans	E. coli	E. faecalis	S. mutans
Day 1	0.5	0.4	0.7	0.4	0.4	0.8
Day 2	0.6	0.6	1.2	0.5	0.5	1.0
Day 4	0.7	1.1	1.4	0.4	0.4	0.8
Day 6	0.8	0.8	1.7	0.3	0.3	0.6
Day 8	0.5	0.4	1.9	0.5	0.5	0.9
Day 10	0.5	0.5	2.1	0.5	0.5	1.0
Controls
Ciprofloxacin	2.5	2.5	10.0	2.5	2.5	10.0
Diclofenac	NI	NI	NI	NI	NI	NI
Drug free fibres (Day 1–10)	NI	NI	NI	NI	NI	NI
PBS pH 4.0	NI	NI	NI	NI	NI	NI
Broth with culture	NI	NI	NI	NI	NI	NI
Broth	NG	NG	NG	NG	NG	NG

NI: no inhibition; NG: no growth. All values are expressed as 𝜇g/mL.