Heat Shock Proteins: Stimulators of Innate and Acquired Immunity

Table 1

Major prokaryotic and eukaryotic families of HSPs and their characteristics (see [15, 16]).

Hsp family	Structural features	Members	Intracellular location
Small HSPs	Varied, often large oligomeric structures	hsp10, GroES, hsp16, α-crystallin, hsp20, hsp25, hsp26, hsp27	Cytosol
HSP40	Dimeric	hsp40, DnaJ, Sis1	Cytosol
HSP47	Monomer; Trimer	hsp47	Endoplasmic reticulum (ER)
CCT	hetero-oligomeric complex	TRiC (60 Kd family)	cytosol
Calreticulin	Monomeric	Calreticulin, Calnexin	ER
HSP60	2 stacked heptameric rings	hsp60, hsp65, GroEL	Cytosol; Mitochondria
HSP70	Monomeric	hsp71, hsc70 (hsp73), hsp110/SSE, DnaK, SSC1, SSQ1, ECM10, Grp78 (BiP), Grp170	Cytosol; Mitochondria; ER
HSP90	Noncovalent homodimers	hsc84, hsp86, HTPG, Gp96 (Grp94, endoplasmin)	Cytosol; ER
HSP100	Multimeric complexes with hsp70 and hsp25	hsp104, Hsp110, Clp proteins, Hsp78	Cytosol; Mitochondria