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BioMed Research International
Volume 2013 (2013), Article ID 463168, 4 pages
http://dx.doi.org/10.1155/2013/463168
Research Article

Highly Ordered Architecture of MicroRNA Cluster

1Department of Geriatric Cardiology, Beijing Military General Hospital, Beijing 100700, China
2The 14th Beijing High School, Beijing, 100020, China
3School of Computer Science and Engineering, Hebei University of Technology, Tianjin 300401, China

Received 18 July 2013; Accepted 3 September 2013

Academic Editor: Qinghua Cui

Copyright © 2013 Bing Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology.