Table 4: Fracture outcomes in community and mixed population studies.

DurationRegimenCompliance (%)Total fracture patients (%)Non-vertebral fracture patients (%)Hip fracture patients (%)

RECORDMedian 45 months (range 24–62)D/CaD47–60353 (13)349 (13)93 (4)
CaP/P345 (13)341 (12)90 (3)
RRRNSNSNS
PorthouseMedian 25 months (range 18–42)CaD6358 (4)NA8 (1)
P91 (5)NA17 (1)
RRRNSNANS
WHI
subgroup
7 years (mean)CaD59NANA115 (3)
PNANA93 (4)
RRRNANANS
HeikinheimoRange 2–5 yearsDNA56 (16)48 (14)25 (7)
P100 (22)94 (21)43 (9)
RRRNR ( )NANS
LipsMaximum 3.5 yearsD85NA135 (10)58 (4)
PNA122 (9)48 (4)
RRRNANSNS
Smith3 yearsDNANA306 (6)66 (1)
PNA279 (6)44 (1)
RR
Increase
NANS49% ( )

ITT analysis unless otherwise stated. D: vitamin D; CaD: calcium and vitamin D combination treatment; P: placebo or control; RRR: relative risk reduction; NA: not available; NS: not significant; RRR: relative risk reduction; NS: not significant; NR: not reported; NA: not available.