Table 6: Effect of vitamin D on bone turnover markers.

Sample sizeTimeRegimen25(OH)D (nmol/ )PTH (pmol/L)ALP (U/L)
BaselineFollowupBaselineFollowupBaselineFollowup

Chapuy 14218 monthsCaD
P

* 

* 



Decalyos II5832 yearsCaD fixed
CaD split
P




NR




NA
NA
NA
NA
NA
NA

RECORD601 yearCaD
D
P
Combined


Combined


NA
NA
NA
NA
NA
NA

Zhu 3021 yearCaD
Ca

+34%* 
NA

% 
%
NA
NA
NA
NA

Kyphos sub-study 1205 yearsCaD
Ca
P






NA
NA
NA



NA
NA

Heikinheimo
residential
33Final treatment + 1 yearD
P
NA
NA

NA
NA
NA
NA
NR
NR
NR
NR

Heikinheimo
community
29Final treatment + 1 yearD
P
NA
NA

NA
NA
NA
NA
NR
NR
NR
NR

Lips963 yearsD
P
NA
NA
54
(43–61)#
23
(17–28)
NA
NA
NA
NA
NA
NA
NA
NA

Ooms2701 yearD
P
27
(19–36)
26
(19–37)
62
(52–70)#
23
(17–31)
3.3
(2.4–4.6)
3.5
(2.7–5.0)
3.1
(2.3–4.1)
3.7
(2.5–5.8)
63
(53–78)
66
(55–78)
62
(53–74)
66
(54–76)

Meyer701 yearD
P

#  

  
NA
NA
NA
NA

Lyons102At least 5 dosesD
P
NA
NA

54.0
NA
NA
  
6.65
NA
NA
NA
NA

Smith434/12D
P
Combined
+21%
NA
4.8 (3.9–5.6) −17%
NA
NA
NA
NA
NA

Ca: calcium; D: vitamin D; P: placebo; NA: not available; NR: not recorded; : decreased; : increased.
Plus-minus values: means ± SD. Values followed parentheses: median (interquartile range). Results nonsignificant unless indicated.   To convert to ng/mL divide by 2.5.  * compared to baseline.   compared to baseline.  # compared to placebo.   compared to placebo.   Difference between means 10.4 ng/mL (95% CI: 6.6–14.2).   Difference between means 1.65 pmol/L (95% CI: 0.54–2.74).