Research Article
Molecular Characterization and Clinical Impact of TMPRSS2-ERG Rearrangement on Prostate Cancer: Comparison between FISH and RT-PCR
Table 2
Correlation between the mechanism of the rearrangement and the clinical and pathological parameters.
| | Parameters | TMPRSS2-ERG negative (%) | Break apart (%) | Interstitial deletion (%) | |
| | PSA | | | | | | <10 ng/mL | 85 (47) | 73 (73) | 23 (23) | | | 10–20 ng/mL | 29 (45.3) | 29 (45.3) | 6 (9.4) | 0.907 | | >20 ng/mL | 18 (43.9) | 17 (41.4) | 6 (14.6) | | | Gleason-sp | | | | | | 2–6 | 56 (49.6) | 45 (39.8) | 12 (10.6) | | | 7 | 57 (41.9) | 61 (44.9) | 18 (13.2) | 0.693 | | >7 | 19 (51.4) | 13 (35.1) | 5 (13.5) | | | cT | | | | | | ≤cT2b | 122 (45.9) | 109 (41) | 23 (23) | 0.251 | | ≥cT3a | 9 (50) | 9 (50) | 0 (0) | | pT | | | | | | ≤pT2 | 75 (48.7) | 60 (39) | 19 (12.3) | 0.639 | | ≥pT3 | 57 (43.5) | 58 (44.3) | 16 (12.2) | | pN* | | | | | | pN0 | 84 (45.4) | 75 (40.5) | 26 (14.1) | 0.177 | | pN ≥1 | 2 (20) | 7 (70) | 1 (10) | | Perineural invasion | | | | | | Negative | 63 (51.2) | 44 (35.8) | 16 (13) | 0.054 | | Positive | 53 (38.1) | 70 (50.4) | 16 (11.5) |
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