About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 468963, 7 pages
http://dx.doi.org/10.1155/2013/468963
Research Article

Stat3 Inhibits PTPN13 Expression in Squamous Cell Lung Carcinoma through Recruitment of HDAC5

1The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China
2Department of Urology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, China
3Department of Gynaecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China

Received 20 July 2013; Revised 17 August 2013; Accepted 30 August 2013

Academic Editor: Qinghua Nie

Copyright © 2013 Xiu-juan Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Wang, D. Shen, D. W. Parsons et al., “Mutational analysis of the tyrosine phosphatome in colorectal cancers,” Science, vol. 304, no. 5674, pp. 1164–1166, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Freiss and D. Chalbos, “PTPN13/PTPl1: an important regulator of tumor aggressiveness,” Anti-Cancer Agents in Medicinal Chemistry, vol. 11, no. 1, pp. 78–88, 2011. View at Scopus
  3. I. Laczmanska and M. M. Sasiadek, “Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer,” Acta Biochimica Polonica, vol. 58, no. 4, pp. 467–470, 2011. View at Scopus
  4. J. Niu, Y.-J. Huang, L.-E. Wang, E. M. Sturgis, and Q. Wei, “Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck,” Carcinogenesis, vol. 30, no. 12, pp. 2053–2058, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Frau, M. M. Simile, and M. L. Tomasi, “An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis,” Cellular Oncology, vol. 35, pp. 163–173, 2012. View at Publisher · View at Google Scholar
  6. M. Glondu-Lassis, M. Dromard, M. Lacroix-Triki et al., “PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase,” Cancer Research, vol. 70, no. 12, pp. 5116–5126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. P. D. Vermeer, M. Bell, K. Lee et al., “ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers,” PLoS ONE, vol. 7, no. 1, Article ID e30447, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Scrima, C. De Marco, F. De Vita et al., “The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in nonsmall cell lung cancer,” American Journal of Pathology, vol. 180, no. 3, pp. 1202–1214, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Yu and R. Jove, “The stats of cancer—new molecular targets come of age,” Nature Reviews Cancer, vol. 4, no. 2, pp. 97–105, 2004. View at Scopus
  10. H. Yu, D. Pardoll, and R. Jove, “STATs in cancer inflammation and immunity: a leading role for STAT3,” Nature Reviews Cancer, vol. 9, no. 11, pp. 798–809, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Grivennikov, E. Karin, J. Terzic et al., “IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer,” Cancer Cell, vol. 15, no. 2, pp. 103–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Hedvat, D. Huszar, A. Herrmann et al., “The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors,” Cancer Cell, vol. 16, no. 6, pp. 487–497, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Lin, Z. Cui, L. Kong, F. Cheng, J. Xu, and F. Lan, “p73 participates in WWOX-mediated apoptosis in leukemia cells,” International Journal of Molecular Medicine, vol. 31, pp. 849–854, 2013.
  14. H. Lee, A. Herrmann, J.-H. Deng et al., “Persistently activated Stat3 maintains constitutive NF-κB activity in tumors,” Cancer Cell, vol. 15, no. 4, pp. 283–293, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Tang, Y. Luo, Z. Jiang, et al., “Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation,” Stem Cells, vol. 30, pp. 2645–2656, 2012. View at Publisher · View at Google Scholar
  16. S.-H. Song, S.-W. Han, and Y.-J. Bang, “Epigenetic-based therapies in cancer: progress to date,” Drugs, vol. 71, no. 18, pp. 2391–2403, 2011. View at Scopus
  17. M. Parra and E. Verdin, “Regulatory signal transduction pathways for class IIa histone deacetylases,” Current Opinion in Pharmacology, vol. 10, no. 4, pp. 454–460, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Ye, M. Llorian, M. Cardona, et al., “A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart,” Journal of Cell Science, vol. 126, pp. 1682–1691, 2013. View at Publisher · View at Google Scholar
  19. P. Peixoto, V. Castronovo, N. Matheus et al., “HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells,” Cell Death and Differentiation, vol. 19, pp. 1239–1252, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. D. A. Moreno, C. A. Scrideli, M. A. A. Cortez et al., “Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia: research paper,” British Journal of Haematology, vol. 150, no. 6, pp. 665–673, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Milde, I. Oehme, A. Korshunov et al., “HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth,” Clinical Cancer Research, vol. 16, no. 12, pp. 3240–3252, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Patani, W. G. Jiang, R. F. Newbold, and K. Mokbel, “Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer,” Anticancer Research, vol. 31, no. 12, pp. 4115–4126, 2011. View at Scopus
  23. J. E. Shabason, P. J. Tofilon, and K. Camphausen, “HDAC inhibitors in cancer care,” Oncology, vol. 24, no. 2, pp. 180–185, 2010. View at Scopus
  24. O. Khan and N. B. La Thangue, “HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications,” Immunology and Cell Biology, vol. 90, no. 1, pp. 85–94, 2012. View at Publisher · View at Google Scholar · View at Scopus