Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats

Table 2

Effects of paracetamol injury and A. blazei pretreatment on plasma enzyme activities, albumin levels, and bilirubin concentration. For experimental details see Section 2.

Parameters	Groups
	I, control	II, A. blazei pretreatment	III, paracetamol injury	IV, A. blazei pretreatment + paracetamol injury
Aspartate aminotransferase (AST, U/L)	74.6 ± 9.3 (𝑛=4)	71.6 ± 4.0 (𝑛=4)	512.9 ± 62.7 (𝑛=4)^a,b,c	246.6 ± 65.2 (𝑛=4)^d,e
Alanine aminotransferase (ALT, U/L)	65.3 ± 4.2 (𝑛=5)	63.7 ± 2.6 (𝑛=4)	447.0 ± 52.0 (𝑛=4)^a,b,c	280.2 ± 64.0 (𝑛=4)^d,e
Lactate dehydrogenase (LDH, U/L)	248.9 ± 12.5 (𝑛=4)	227.7 ± 38.1 (𝑛=4)	531.0 ± 36.8 (𝑛=5)^a,b,c	304.4 ± 24.7 (𝑛=4)
Alkaline phosphatase; (ALP, U/L)	74.6 ± 14.8 (𝑛=4)	72.6 ± 3.6 (𝑛=4)	174.1 ± 16.2 (𝑛=5)^a,b,c	123.3 ± 5.6 (𝑛=5)^d,e
Albumin (g/L)	2.37 ± 0.09 (𝑛=5)	2.21 ± 0.14 (𝑛=5)	2.48 ± 0.20 (𝑛=4)	2.22 ± 0.10 (𝑛=6)
Total bilirubin (mg/dL)	0.53 ± 0.01 (𝑛=4)	0.35 ± 0.01 (𝑛=4)	0.80 ± 0.01 (𝑛=5)^b	0.64 ± 0.11 (𝑛=6)^e
Conjugated bilirubin (mg/dL)	0.07 ± 0.01 (𝑛=4)	0.07 ± 0.01 (𝑛=4)	0.24 ± 0.01 (𝑛=4)^a,b,c	0.17 ± 0.01 (𝑛=6)^d,e

Significant differences (𝑃≤0.05), according to one-way ANOVA followed by Student-Newman-Keuls post-hoc testing, are identified by the superscript letters as follows: ^aIII versus I; ^bIII versus II; ^cIII versus IV; ^dIV versus I; ^eIV versus II.