Table 5: Effects of paracetamol injury and A. blazei pretreatment on metabolic parameters of perfused rat livers metabolizing exogenously supplied alanine. Livers from fasted rats were perfused according to the experimental protocol illustrated by Figure 2. For additional experimental details and see Section 2.

Metabolic fluxes (µmol min−1 g−1) I, control II, A. blazei pretreatment III, paracetamol injury IV, A. blazei pretreatment + paracetamol injury

Lactate production0.31 ± 0.03 ( )0.25 ± 0.03 ( )0.62 ± 0.05 ( )a,b,c0.35 ± 0.02 ( )
Pyruvate production0.13 ± 0.02 ( )0.082 ± 0.030 ( )0.29 ± 0.05 ( )a,b0.20 ± 0.02 ( )
Glucose production0.25 ± 0.02 ( )0.21 ± 0.02 ( )0.092 ± 0.020 ( )a,b0.060 ± 0.030 ( )d,e
Oxygen consumption0.39 ± 0.06 ( )0.23 ± 0.05 ( )0.32 ± 0.07 ( )0.29 ± 0.03 ( )
Ammonia production0.058 ± 0.010 ( )0.085 ± 0.030 ( )0.20 ± 0.03 ( )a,b0.16 ± 0.01 ( )d
Urea production0.28 ± 0.01 ( ) 0.12 ± 0.01 ( )f,g0.23 ± 0.03 ( )b0.25 ± 0.05 ( )

Significant differences ( ), according to one-way ANOVA followed by Student-Newman-Keuls post-hoc testing, are identified by the superscript letters as follows: aIII versus I; bIII versus II; cIII versus IV; dIV versus I; eIV versus II; fII versus I; gII versus IV.