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BioMed Research International
Volume 2013 (2013), Article ID 472347, 9 pages
Research Article

Significance of Coronary Calcification for Prediction of Coronary Artery Disease and Cardiac Events Based on 64-Slice Coronary Computed Tomography Angiography

1Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
2Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, WA 6845, Australia
3Department of Public Health and Center of Biostatistics, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8
5Second Section of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

Received 3 January 2013; Accepted 4 February 2013

Academic Editor: Fan-Lin Kong

Copyright © 2013 Yuan-Chang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This work aims to validate the clinical significance of coronary artery calcium score (CACS) in predicting coronary artery disease (CAD) and cardiac events in 100 symptomatic patients (aged 37–87 years, mean 62.5, 81 males) that were followed up for a mean of 5 years. Our results showed that patients with CAD and cardiac events had significantly higher CACS than those without CAD and cardiac events, respectively. The corresponding data were versus ( ) for CAD, and versus ( ) for cardiac events. Of 72 patients with CAD, cardiac events were found in 56 (77.7%) patients. The prevalence of cardiac events in our cohort was 13.3% for calcium score 0, 50% for score 11–100, 56% for score 101–400, 68.7% for score 401–1,000, and 75.0% for score >1000. Increased CACS (>100) was also associated with an increased frequency of multi-vessel disease. Nonetheless, 3 (20%) out of 15 patients with zero CACS had single-vessel disease. Significant correlation ( ) was observed between CACS and CAD on a vessel-based analysis for coronary arteries. It is concluded that CACS is significantly correlated with CAD and cardiac events.