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BioMed Research International
Volume 2013 (2013), Article ID 474272, 9 pages
Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
1Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, Xinjiang 832002, China
2Binzhou Medical College, Yantai, Shandong 264000, China
3Life Science School, Yantai University, Yantai, Shandong 264000, China
Received 12 April 2013; Revised 3 June 2013; Accepted 3 June 2013
Academic Editor: Thomas Liehr
Copyright © 2013 Xuan Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- K. Zieger, “High throughput molecular diagnostics in bladder cancer—on the brink of clinical utility,” Molecular Oncology, vol. 1, no. 4, pp. 384–394, 2008.
- D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA: A Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005.
- P. E. Clark, “Bladder cancer,” Current Opinion in Oncology, vol. 19, no. 3, pp. 241–247, 2007.
- S. Pichu, S. Krishnamoorthy, A. Shishkov, B. Zhang, P. McCue, and B. C. Ponnappa, “Knockdown of Ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition,” PLoS ONE, vol. 7, no. 11, Article ID e48567, 2012.
- W. Tan, J. Lu, M. Huang et al., “Anti-cancer natural products isolated from chinese medicinal herbs,” Chinese Medicine, vol. 6, article 27, 2011.
- R. Gerl and D. L. Vaux, “Apoptosis in the development and treatment of cancer,” Carcinogenesis, vol. 26, no. 2, pp. 263–270, 2005.
- A. Gosslau and K. Y. Chen, “Nutraceuticals, apoptosis, and disease prevention,” Nutrition, vol. 20, no. 1, pp. 95–102, 2004.
- I. Böhm and H. Schild, “Apoptosis: the complex scenario for a silent cell death,” Molecular Imaging and Biology, vol. 5, no. 1, pp. 2–14, 2003.
- J. Moungjaroen, U. Nimmannit, P. S. Callery et al., “Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation,” Journal of Pharmacology and Experimental Therapeutics, vol. 319, no. 3, pp. 1062–1069, 2006.
- M. Ott, V. Gogvadze, S. Orrenius, and B. Zhivotovsky, “Mitochondria, oxidative stress and cell death,” Apoptosis, vol. 12, no. 5, pp. 913–922, 2007.
- F. Klamt, F. Dal-Pizzol, M. L. C. da Frota Jr. et al., “Imbalance of antioxidant defense in mice lacking cellular prion protein,” Free Radical Biology and Medicine, vol. 30, no. 10, pp. 1137–1144, 2001.
- G. Ermak and K. J. A. Davies, “Calcium and oxidative stress: from cell signaling to cell death,” Molecular Immunology, vol. 38, no. 10, pp. 713–721, 2002.
- S. Shankar and R. K. Srivastava, “Involvement of Bcl-2 family members, phosphatidylinositol 3′-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer,” International Journal of Oncology, vol. 30, no. 4, pp. 905–918, 2007.
- S. Azam, N. Hadi, N. U. Khan, and S. M. Hadi, “Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties,” Toxicology In Vitro, vol. 18, no. 5, pp. 555–561, 2004.
- S. Fujisawa and Y. Kadoma, “Anti- and pro-oxidant effects of oxidized quercentin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method,” In Vivo, vol. 20, no. 1, pp. 39–44, 2006.
- X. Y. Xiao, M. Hao, X. Y. Yang et al., “Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis,” Cancer Letters, vol. 302, no. 1, pp. 69–75, 2011.
- Y. Y. Yo, G. S. Shieh, K. F. Hsu, C. L. Wu, and A. L. Shiau, “Licorice and licochalcone-a induce autophagy in lncap prostate cancer cells by suppression of bcl-2 expression and the mtor pathway,” Journal of Agricultural and Food Chemistry, vol. 57, no. 18, pp. 8266–8273, 2009.
- J. K. Kim, E. K. Shin, J. H. Park, Y. H. Kim, and J. H. Y. Park, “Antitumor and antimetastatic effects of licochalcone A in mouse models,” Journal of Molecular Medicine, vol. 88, no. 8, pp. 829–838, 2010.
- T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983.
- J. I. Jung, S. S. Lim, H. J. Choi et al., “Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells,” Journal of Nutritional Biochemistry, vol. 17, no. 10, pp. 689–696, 2006.
- X. Yuan, B. Zhang, N. Chen et al., “Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells,” Journal of Asian Natural Products Research, vol. 14, no. 8, pp. 789–798, 2012.
- X. Yuan, B. Yu, Y. Wang et al., “Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis,” Recent Patents on Anti-Cancer Drug Discovery, vol. 8, no. 2, pp. 191–199, 2013.
- D. Hockenbery, G. Nunez, C. Milliman, R. D. Schreiber, and S. J. Korsmeyer, “Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death,” Nature, vol. 348, no. 6299, pp. 334–336, 1990.
- M. Reers, T. W. Smith, and L. B. Chen, “J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential,” Biochemistry, vol. 30, no. 18, pp. 4480–4486, 1991.
- S. T. Smiley, M. Reers, C. Mottola-Hartshorn et al., “Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 9, pp. 3671–3675, 1991.
- D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011.
- L. F. Zerbini, R. E. Tamura, R. G. Correa et al., “Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy,” PLoS ONE, vol. 6, no. 9, Article ID e24285, 2011.
- M. O. Hengartner, “The biochemistry of apoptosis,” Nature, vol. 407, no. 6805, pp. 770–776, 2000.
- J. M. Brown and B. G. Wouters, “Apoptosis, p53, and tumor cell sensitivity to anticancer agents,” Cancer Research, vol. 59, no. 7, pp. 1391–1399, 1999.
- C. K. Lee, S. H. Son, K. K. Park et al., “Licochalcone a inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice,” Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 1, pp. 48–54, 2008.
- M. M. Rafi, R. T. Rosen, A. Vassil et al., “Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid,” Anticancer Research, vol. 20, no. 4, pp. 2653–2658, 2000.
- M. Rottner, S. Tual-Chalot, H. A. Mostefai, R. Andriantsitohaina, J. Freyssinet, and M. C. Martínez, “Increased oxidative stress induces apoptosis in human cystic fibrosis cells,” PLoS ONE, vol. 6, no. 9, Article ID e24880, 2011.
- M. Jastroch, “Unraveling the molecular machinery that promotes pancreatic β-cell dysfunction during oxidative stress: focus on ‘phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1’,” The American Journal of Physiology, vol. 300, no. 1, pp. R9–R11, 2011.
- D. Ron and P. Walter, “Signal integration in the endoplasmic reticulum unfolded protein response,” Nature Reviews Molecular Cell Biology, vol. 8, no. 7, pp. 519–529, 2007.
- C. Hetz, “The unfolded protein response: controlling cell fate decisions under ER stress and beyond,” Nature Reviews Molecular Cell Biology, vol. 13, no. 2, pp. 89–102, 2012.
- D. G. Breckenridge, M. Germain, J. P. Mathai, M. Nguyen, and G. C. Shore, “Regulation of apoptosis by endoplasmic reticulum pathways,” Oncogene, vol. 22, no. 53, pp. 8608–8618, 2003.
- I. L. Hsin, Y. C. Hsiao, M. F. Wu et al., “Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells,” Toxicology and Applied Pharmacology, vol. 263, no. 3, pp. 330–337, 2012.
- J. Wang, X. Fang, and W. Liang, “Pegylated phospholipid micelles induce endoplasmic reticulum-dependent apoptosis of cancer cells but not normal cells,” The American Chemical Society Nano, vol. 6, no. 6, pp. 5018–5030, 2012.
- L. Yuzefovych, G. Wilson, and L. Rachek, “Different effects of oleate versus palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress,” The American Journal of Physiology, vol. 299, no. 6, pp. E1096–E1105, 2010.