Table 1: Neurological Disability Clinical Scoring System for EAE animals induced to a state of MS. The total score is the sum of the following individual scores obtained for each of the 6 specified clinical domains. Following induction, each rat was assessed twice daily for clinical signs of EAE as previously described [27] thereby rendering an average daily mean score. EAE animals after disease onset were assessed three times daily thereby rendering an average daily mean score. Daily body weight and hydration status were also measured to assess general animal health and well-being.

TailBladder

0—normal 0—normal
1—partially paralyzed, weakness 1—incontinence
2—completely paralyzed, limp

Right hindlimb Left hindlimb

0—normal 0—normal
1—weakness 1—weakness
2—dragging with partial paralysis 2—dragging with partial paralysis
3—complete paralysis 3—complete paralysis

Right forelimbLeft forelimb

0—normal 0—normal
1—weakness 1—weakness
2—dragging, not able to support weight 2—dragging, not able to support weight
3—complete paralysis 3—complete paralysis