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BioMed Research International
Volume 2013 (2013), Article ID 481843, 8 pages
http://dx.doi.org/10.1155/2013/481843
Clinical Study

Effect of Fluorometholone/Tetrahydrozoline Fixed Combination on Conjunctival Autograft Morphology after Primary Pterygium Excision

1Beyoglu Eye Research and Training Hospital, 34001 Istanbul, Turkey
2Department of Ophthalmology, Gaziantep Sehitkamil State Hospital, Gaziantep, Turkey
3Department of Ophthalmology, Canakkale Onsekiz Mart University, Canakkale, Turkey
4Department of Ophthalmology, Istanbul Medeniyet University Medical School, Istanbul, Turkey

Received 3 April 2013; Accepted 1 June 2013

Academic Editor: Marcel N. Menke

Copyright © 2013 Engin Bilge Ozgurhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the effect of a fluorometholone/tetrahydrozoline fixed combination on conjunctival graft morphology after primary pterygium excision. Methods. The patients who underwent pterygium excision with conjunctival autograft transplantation were randomized into three groups based on postoperative medications as the fluorometholone/tetrahydrozoline group, fluorometholone group, and dexamethasone group. Conjunctival graft thickness was measured with anterior segment optical coherence tomography. The conjunctival graft hyperemia was evaluated using a high definition external camera. Results. The mean graft thickness was significantly lower in the fluorometholone/tetrahydrozoline group compared with fluorometholone and dexamethasone groups at 2 weeks ( and , resp.) and at 1 month after surgery ( and , resp.). The conjunctival hyperemia score was significantly lower in the fluorometholone/tetrahydrozoline group compared with fluorometholone and dexamethasone groups at 2 weeks ( and , resp.) and at 1 month ( and , resp.). The graft thickness and conjunctival hyperemia score were similar among the groups at 1 week and 3 months ( ). Conclusion. The findings of the present study revealed that treatment with the fluorometholone/tetrahydrozoline fixed combination may be helpful to decrease graft edema and to achieve better cosmetic appearance at 2 weeks and 1 month after pterygium excision.