NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study

Table 5

The allele frequency distribution of HLA-DRB1 and HLA-DQB1 genes in the controls and TB patients of the Chinese Kazakh population.

Alleles	Tuberculosis; 𝑁 (Freq)	Control; 𝑁 (Freq)	𝜒^2	OR (95% CI)	𝑃
HLA-DRB1
01	19 (4.2)	17 (3.77)	0.111	1.123 (0.568–2.220)	0.739
03	12 (5.19)	7 (1.53)	1.350	1.746 (0.675–4.516)	0.245
04	51 (11.72)	30 (6.75)	6.495	1.889 (1.153–3.095)	0.011
07	30 (12.99)	24 (5.36)	0.726	1.281 (0.724–2.267)	0.394
08	17 (3.75)	14 (3.09)	0.297	1.226 (0.589–2.549)	0.585
09	7 (1.53)	12 (2.64)	1.395	0.568 (0.219–1.469)	0.238
10	13 (2.86)	5 (1.09)	3.664	2.683 (0.941–7.654)	0.056
11	3 (0.66)	8 (1.76)	2.351	0.365 (0.096–1.394)	0.125
12	19 (4.2)	13 (2.87)	1.181	1.496 (0.721–3.106)	0.277
13	15 (3.3)	12 (2.64)	0.340	1.262 (0.577–2.758)	0.560
14	16 (3.53)	10 (2.2)	1.440	1.637 (0.727–3.688)	0.230
15	42 (18.18)	31 (6.98)	1.913	1.427 (0.861–2.364)	0.617
16	8 (1.75)	6 (1.31)	0.286	1.339 (0.457–1.024)	0.593
HLA-DQB1
0201	103 (25.6)	71 (16.9)	9.231	1.802 (1.230–2.639)	0.002
0301/4	16 (3.5)	13 (2.87)	0.317	1.242 (0.583–2.645)	0.573
0302/3	13 (2.9)	7 (1.53)	1.885	1.900 (0.744–4.852)	0.173
0303	22 (4.88)	18 (3.99)	0.419	1.240 (0.646–2.379)	0.517
0304	19 (4.2)	14 (3.09)	0.793	1.383 (0.676–2.829)	0.373
0401	24 (5.34)	25 (5.59)	0.028	0.951 (0.526–1.719)	0.867
0402	26 (5.79)	32 (7.21)	0.740	0.785 (0.451–1.364)	0.390
0501	47 (10.75)	41 (9.1)	0.474	1.177 (0.739–1.875)	0.491
0502	39 (8.83)	53 (12.27)	2.738	0.678 (0.428–1.076)	0.120
0503	11 (2.41)	9 (1.97)	0.200	1.228 (0.499–3.021)	0.655
0504	17 (3.75)	20 (4.45)	0.279	0.834 (0.425–1.637)	0.597
0601	51 (12.14)	36 (8.16)	3.108	1.527 (0.952–2.449)	0.078
0602	29 (6.49)	38 (8.63)	1.461	0.725 (0.430–1.223)	0.227
0603/8	14 (3.08)	23 (5.13)	2.423	0.581 (0.291–1.159)	0.120
0604	31 (6.95)	25 (5.59)	0.702	1.271 (0.725–2.229)	0.402

Note: 𝑁: the sample size; OR: odds ratio; 95%, CI: 95% confidence interval; Freq: frequency.