The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis

Figure 4

Mean body weight change over a period of 22 days after arthritis induction. Each valuerepresents the mean ± SEM of 𝑛=12 per group. A gradual increase in the body weight of normal control group was observed throughout the course of 22-day experiment. The arthritic control group demonstrated a significant decrease in their body weight from day 4 (*𝑃<0.01) onward. When compared to normal control, the indomethacin- and NHAG-treated arthritic group showed a decline in their body weight from days 14 and 12, achieved significance on day 18 (^*δ𝑃<0.04) and 12 (^*‡𝑃<0.04), respectively. However, the reduction was significantly lower when compared to the arthritic control group on day 8 (^δ𝑃<0.008) and day 12 (^‡𝑃<0.03) and continued till end of experiment (**𝑃<0.04) and (***𝑃<0.004) for indomethacin- and NHAG-treated groups, resp.).