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BioMed Research International
Volume 2013 (2013), Article ID 495319, 8 pages
http://dx.doi.org/10.1155/2013/495319
Research Article

Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine

1Department of Pharmacy, Faculty of Medicine, Universiti of Malaya, 50603 Kuala Lumpur, Malaysia
2Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Selangor, Serdang, Malaysia
3Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Received 30 May 2013; Accepted 8 July 2013

Academic Editor: Ibrahim Banat

Copyright © 2013 Ehsan Taghizadeh Davoudi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets of Capecitabine, which is approved by the Food and Drug Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl methylcellulose (HPMC), carbomer934P, sodium alginate, and sodium bicarbonate. Tablets were prepared using the wet granulation method and characterized such that floating lag time, total floating time, hardness, friability, drug content, weight uniformity, and in vitro drug release were investigated. The sustained release tablets showed good hardness and passed the friability test. The tablets’ floating lag time was determined to be 30–200 seconds, and it floated more than 24 hours and released the drug for 24 hours. Then, the stability test was done and compared with the initial samples. In conclusion, by adjusting the right ratios of the excipients including release-retarding gel-forming polymers like HPMC K4M, Na alginate, carbomer934P, and sodium bicarbonate, sustained release Capecitabine floating tablet was formulated.