Liposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Model

Table 1

Quantification of antibacterial and antibiofilm activity of mupirocin samples.

Sample	Biofilm bacteria; IC50, μM; (95% confidence intervals)		Planktonic bacteria; IC50, μM; (95% confidence intervals)
	Prior to biofilm formation	After biofilm formation	Turbidity
	Viability	Viability
Mupirocin	0.27 (0.48–0.70)	50%^a	0.20 (0.42–0.67)
Mupirocin-in-liposomes	0.58 (0.16–0.45)	50%^a	0.53 (0.14–0.26)
Penicillin G	0.13 (0.12–0.14)	45.2%^b	0.10 (0.08–0.13)

aPercentual inhibition at 405 μM.
^bPercentual inhibition at 5 mM. Penicillin G fails to cause more than 45.2% of inhibition of biofilms viability in the postexposure assay, as previously shown in Skogman et al. [14].