With our information to date, we propose a model of Th2 induction in which the excreted/secreted antigens of T. crassiceps (TcES) recruit MDSC populations to downmodulate the early Th1 response, while iDCs and eosinophils recruited by these antigens induce Th2 differentiation. AAMs reinforce Th2 lymphocyte differentiation while limiting their proliferation. Together, these changes favor a dominant Th2 response.