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BioMed Research International
Volume 2013 (2013), Article ID 501203, 9 pages
http://dx.doi.org/10.1155/2013/501203
Clinical Study

Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study

1Department of Surgery, 2nd Surgical Clinic, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 4-6 Clinicilor, 400006 Cluj-Napoca, Romania
2Biotechnology Platform, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăştur, 400372 Cluj-Napoca, Romania
3Department of Medical Informatics and Biostatistics, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 6 Louis Pasteur, 400349 Cluj-Napoca, Romania

Received 30 March 2013; Revised 19 May 2013; Accepted 20 May 2013

Academic Editor: Konstantinos Kantartzis

Copyright © 2013 Claudia D. Gherman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. We hypothesized that adiponectin gene SNP+45 (rs2241766) and SNP+276 (rs1501299) would be associated with atherosclerotic peripheral arterial disease (PAD). Furthermore, the association between circulating adiponectin levels, fetuin-A, and tumoral necrosis factor-alpha (TNF- ) in patients with atherosclerotic peripheral arterial disease was investigated. Method. Several blood parameters (such as adiponectin, fetuin-A, and TNF- ) were measured in 346 patients, 226 with atherosclerotic peripheral arterial disease (PAD) and 120 without symptomatic PAD (non-PAD). Two common SNPs of the ADIPOQ gene represented by +45T/G 2 and +276G/T were also investigated. Results. Adiponectin concentrations showed lower circulating levels in the PAD patients compared to non-PAD patients ( ). Decreasing adiponectin concentration was associated with increasing serum levels of fetuin-A in the PAD patients. None of the investigated adiponectin SNPs proved to be associated with the subjects’ susceptibility to PAD ( ). Conclusion. The results of our study demonstrated that neither adiponectin SNP+45 nor SNP+276 is associated with the risk of PAD.