About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 501203, 9 pages
http://dx.doi.org/10.1155/2013/501203
Clinical Study

Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study

1Department of Surgery, 2nd Surgical Clinic, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 4-6 Clinicilor, 400006 Cluj-Napoca, Romania
2Biotechnology Platform, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăştur, 400372 Cluj-Napoca, Romania
3Department of Medical Informatics and Biostatistics, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 6 Louis Pasteur, 400349 Cluj-Napoca, Romania

Received 30 March 2013; Revised 19 May 2013; Accepted 20 May 2013

Academic Editor: Konstantinos Kantartzis

Copyright © 2013 Claudia D. Gherman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. W. Hallett, “Peripheral arterial disease,” in The Merck Manual, R. S. Porter and J. L. Kaplan, Eds., 2008, http://www.merckmanuals.com/professional/cardiovascular_disorders/peripheral_arterial_disorders/peripheral_arterial_disease.html?qt=peripheral%20arterial%20disease&alt=sh.
  2. C. L. Heald, F. G. R. Fowkes, G. D. Murray, and J. F. Price, “Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review,” Atherosclerosis, vol. 189, no. 1, pp. 61–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Creager and J. Loscalzo, “Vascular diseases of the extremities,” in Harrison's Principles of Internal Medicine, A. S. Fauci, E. Braunwald, and D. L. Kasper, Eds., McGraw Hill, New York, NY, USA, 17 edition, 2008.
  4. A. T. Hirsch, M. H. Criqui, D. Treat-Jacobson et al., “Peripheral arterial disease detection, awareness, and treatment in primary care,” Journal of the American Medical Association, vol. 286, no. 11, pp. 1317–1324, 2001. View at Scopus
  5. M. M. McDermott, P. Greenland, K. Liu et al., “Leg symptoms in peripheral arterial disease associated clinical characteristics and functional impairment,” Journal of the American Medical Association, vol. 286, no. 13, pp. 1599–1606, 2001. View at Scopus
  6. M. Makowsky, M. S. McMurtry, T. Elton et al., “Prevalence and Treatment patterns of lower extremity peripheral arterial disease among patients at risk in ambulatory health settings,” Canadian Journal of Cardiology, vol. 27, no. 3, pp. 389.e11–389.e18, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Cimminiello, S. Kownator, J. Wautrecht et al., “The PANDORA study: peripheral arterial disease in patients with non-high cardiovascular risk,” Internal and Emergency Medicine, vol. 6, no. 6, pp. 509–519, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Dorobanţu, C. Tîrziu, S. Ghiorghe, E. Găinoiu, and D. Zamfir, “The prevalence of peripheral arterial disease in relationship with cardiovascular risk factors in Romania,” Romanian Journal of Internal Medicine, vol. 47, no. 4, pp. 363–369, 2009.
  9. V. Aboyans, I. Desormais, P. Lacroix, J. Salazar, M. H. Criqui, and M. Laskar, “The general prognosis of patients with peripheral arterial disease differs according to the disease localization,” Journal of the American College of Cardiology, vol. 55, no. 9, pp. 898–903, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. J. D. Knudson, G. M. Dick, and J. D. Tune, “Adipokines and coronary vasomotor dysfunction,” Experimental Biology and Medicine, vol. 232, no. 6, pp. 727–736, 2007. View at Scopus
  11. C. Jung, E. Rhee, S. Kim et al., “Associations between two single nucleotide polymorphisms of adiponectin gene and coronary artery diseases,” Endocrine Journal, vol. 53, no. 5, pp. 671–677, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Karaseka, H. Vaverkova, M. Halenka, D. Jackuliakova, Z. Frysak, and D. Novotny, “Total adiponectin levels in dyslipidemic individuals: relationship to metabolic parameters and intima-media thickness,” Biomedical Papers, vol. 155, no. 1, pp. 55–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Arita, S. Kihara, N. Ouchi et al., “Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell,” Circulation, vol. 105, no. 24, pp. 2893–2898, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Li, H. J. Shin, E. L. Ding, and R. M. Van Dam, “Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis,” Journal of the American Medical Association, vol. 302, no. 2, pp. 179–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Antoniades, A. S. Antonopoulos, D. Tousoulis, and C. Stefanadis, “Adiponectin: from obesity to cardiovascular disease: etiology and Pathophysiology,” Obesity Reviews, vol. 10, no. 3, pp. 269–279, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Dieplinger, W. Poelz, M. Haltmayer, and T. Mueller, “Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease,” Clinical Chemistry and Laboratory Medicine, vol. 44, no. 7, pp. 830–833, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. M. Hennige, H. Staiger, C. Wicke et al., “Fetuin-A induces cytokine expression and suppresses adiponectin production,” PLoS ONE, vol. 3, no. 3, Article ID e1765, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Ix, M. G. Shlipak, V. M. Brandenburg, S. Ali, M. Ketteler, and M. A. Whooley, “Association between human fetuin-A and the metabolic syndrome: data from the heart and soul study,” Circulation, vol. 113, no. 14, pp. 1760–1767, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. M. E. Trujillo and P. E. Scherer, “Adipose tissue-derived factors: impact on health and disease,” Endocrine Reviews, vol. 27, no. 7, pp. 762–778, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. I. M. Heid, P. Henneman, A. Hicks et al., “Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals,” Atherosclerosis, vol. 208, no. 2, pp. 412–420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Lau and S. Muniandy, “Adiponectin and resistin gene polymorphisms in association with their respective adipokine levels,” Annals of Human Genetics, vol. 75, no. 3, pp. 370–382, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Shapiro and P. E. Scherer, “The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor,” Current Biology, vol. 8, no. 6, pp. 335–338, 1998. View at Scopus
  23. C. Menzaghi, V. Trischitta, and A. Doria, “Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease,” Diabetes, vol. 56, no. 5, pp. 1198–1209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. C. D. Gherman and A. I. Mironiuc, “Evaluation of serum adipokines in peripheral arterial occlusive disease,” Mediators of Inflammation, vol. 2012, Article ID 257808, 8 pages, 2012. View at Publisher · View at Google Scholar
  25. A. T. Hirsch, Z. J. Haskal, N. R. Hertzer et al., “ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic InterSociety Consensus; and Vascular Disease Foundation,” Circulation, vol. 113, pp. e463–e654, 2006.
  26. A. Keys, F. Fidanza, M. J. Karvonen, N. Kimura, and H. L. Taylor, “Indices of relative weight and obesity,” Journal of Chronic Diseases, vol. 25, no. 6-7, pp. 329–343, 1972. View at Scopus
  27. V. Mackevics, I. M. Heid, S. A. Wagner et al., “The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians,” European Journal of Human Genetics, vol. 14, no. 3, pp. 349–356, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Jäntschi and S. D. Bolboacǎ, “Exact probabilities and confidence limits for binomial samples: applied to the difference between two proportions,” TheScientificWorldJournal, vol. 10, pp. 865–878, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Ouriel, “Peripheral arterial disease,” Lancet, vol. 358, no. 9289, pp. 1257–1264, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Y. Ho, N. R. Cook, K. A. Britton et al., “High-molecular-weight and total adiponectin levels and incident symptomatic peripheral artery disease in women: a prospective investigation,” Circulation, vol. 124, no. 21, pp. 2303–2311, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. S. A. Phillips, J. Kung, T. P. Ciaraldi et al., “Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans,” American Journal of Physiology, vol. 297, no. 3, pp. E767–E773, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. G. Yu, S. Javorschi, A. L. Hevener et al., “The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects,” Diabetes, vol. 51, no. 10, pp. 2968–2974, 2002. View at Scopus
  33. D. P. Lorant, M. Grujicic, C. Hoebaus et al., “Fetuin-A levels are increased in patients with type 2 diabetes and peripheral arterial disease,” Diabetes Care, vol. 34, no. 1, pp. 156–161, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Torres, N. Cox, and L. Philipson, “Genome wide association studies for diabetes: perspective on results and challenges,” Pediatric Diabetes, vol. 14, no. 2, pp. 90–96, 2013.
  35. L. K. Billings and J. C. Florez, “The genetics of type 2 diabetes: what have we learned from GWAS?” Annals of the New York Academy of Sciences, vol. 1212, pp. 59–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Sabouri, M. Ghayour-Mobarhan, M. Mouhebati et al., “Association between 45T/G polymorphism of adiponectin gene and coronary artery disease in an iranian population,” TheScientificWorldJournal, vol. 11, pp. 93–101, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Lacquemant, P. Froguel, S. Lobbens, P. Izzo, C. Dina, and J. Ruiz, “The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus,” Diabetic Medicine, vol. 21, no. 7, pp. 776–781, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. V. Mackevics, I. M. Heid, S. A. Wagner et al., “The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians,” European Journal of Human Genetics, vol. 14, no. 3, pp. 349–356, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Qi, C. Menzaghi, L. Salvemini, C. De Bonis, V. Trischitta, and F. B. Hu, “Novel locus FER is associated with serum HMW adiponectin levels,” Diabetes, vol. 60, no. 8, pp. 2197–2201, 2011. View at Publisher · View at Google Scholar · View at Scopus