Review Article
Skeletal Muscle Oxygen Saturation (StO2) Measured by Near-Infrared Spectroscopy in the Critically Ill Patients
Table 1
Summarized prognostic studies on StO2 with VOT-derived parameters in septic patients.
| | Study | Patient population () | Inclusion time | StO2 site/depth | VOT | MAP (mmHg) | DeO2
(%/min) | ReO2
(%/sec) | Mortality | Comments |
| | Parežnik et al. [18] | SS (6) and SShock (6) | First 48 h (after stabilization) | TH 15 mm | StO2 40% | — | SS −10.4
(−7.8, −13.3)
SShock −7
(−3.6, −11) | — | No correlation to StO2-derived variables | DeO2 correlated to SOFA score |
| | Creteur et al. [19] | SS and SShock (72) | First 24 h | TH 25 mm | 3 min | 72 (67–79) | — | SShock
2 (1.2, 2.9)
versus
no SShock
3.2 (1.8, 4.5)
() | ReO2 correlated to mortality
SV
NonSV () | AUC 0.797
ReO2 cut-off 2.55
(S 85%, E 73%) |
| | Doerschug et al. [20] | Sepsis (24) | First 24 h | TH 15 mm | 5 min | 69
(max 90, min 55) | — | Moderate sepsis
Severe sepsis
| ReO2 tended to be higher in SV than in NonSV
versus
(P 0.2) | |
| | Skarda et al. [21] | SS and SShock (10) | ICU admission | TH 15 mm | 3 min | | | | No association between StO2 variables and mortality | |
| | Payen et al. [22] | SShock (43) | First 24 h (after vasopressors) | TH 25 mm | 3 min | 75 (65–82) | −18.6
(−28.2, −14.4) | 2.79 (1.75, 4.52) | ReO2 correlated to mortality
SV 3.9 (2.2, 6.0)
NonSV 1.9
(1.6, 2.8)
(P 0.003) | AUC 0.77
ReO2 cut-off 2.83
(S 87%, E 67%) |
| | Mesquida et al. [23] | SShock (33) | First 24 h, once MAP > 65 mmHg | TH 15 mm | StO2 40% | |
SOFAimp
SOFAnonimp
| | DeO2 tended to be lower in NonSV than in SV
(P ns) | DeO2 associated with SOFA evolution and ICU-LOS
ReO2 associated with ICU-LOS |
|
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StO2: tissue oxygen saturation; VOT: vascular occlusion test; DeO2: StO2-deoxygenation slope; ReO2: StO2-reoxygenation slope; SS: severe sepsis; SShock: septic shock; TH: thenar; SOFA: sequential organ failure assessment; SV: survivors; NonSV: nonsurvivors; AUC: area under the curve; SOFAimp: SOFA improvers at day 2; SOFAnonimp: SOFA nonimprovers at day 2; LOS: length of stay.
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