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BioMed Research International
Volume 2013 (2013), Article ID 503047, 15 pages
Characterization of Cardiac-Resident Progenitor Cells Expressing High Aldehyde Dehydrogenase Activity
1Department of Cardiology, Centre Hospitalier Universitaire Vaudois (CHUV), Avenue du Bugnon, 1011 Lausanne, Switzerland
2Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Avenue du Bugnon, 1011 Lausanne, Switzerland
3Molecular Cardiology Laboratory, Fondazione Cardiocentro Ticino, Via Tesserete 48, 6900 Lugano, Switzerland
Received 16 August 2012; Revised 29 October 2012; Accepted 2 November 2012
Academic Editor: Franca Di Meglio
Copyright © 2013 Marc-Estienne Roehrich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. Oh, S. B. Bradfute, T. D. Gallardo et al., “Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 21, pp. 12313–12318, 2003.
- A. P. Beltrami, L. Barlucchi, D. Torella et al., “Adult cardiac stem cells are multipotent and support myocardial regeneration,” Cell, vol. 114, no. 6, pp. 763–776, 2003.
- K. L. Laugwitz, A. Moretti, J. Lam et al., “Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages,” Nature, vol. 433, no. 7026, pp. 647–653, 2005.
- K. L. Laugwitz, A. Moretti, J. Lam et al., “Erratum: Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages,” Nature, vol. 446, no. 7138, p. 934, 2007.
- J. Cai, M. L. Weiss, and M. S. Rao, “In search of “stemness”,” Experimental Hematology, vol. 32, no. 7, pp. 585–598, 2004.
- A. E. Balber, “Concise review: aldehyde dehydrogenase bright stem and progenitor cell populations from normal tissues: characteristics, activities, and emerging uses in regenerative medicine,” Stem Cells, vol. 29, no. 4, pp. 570–575, 2011.
- D. J. Laird, A. W. De Tomaso, and I. L. Weissman, “Stem cells are units of natural selection in a colonial ascidian,” Cell, vol. 123, no. 7, pp. 1351–1360, 2005.
- D. J. Laird, A. W. De Tomaso, and I. L. Weissman, “Erratum: Stem cells are units of natural selection in a colonial ascidian,” Cell, vol. 124, no. 3, pp. 647–648, 2006.
- S. A. Marchitti, C. Brocker, D. Stagos, and V. Vasiliou, “Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily,” Expert Opinion on Drug Metabolism and Toxicology, vol. 4, no. 6, pp. 697–720, 2008.
- M. B. Kastan, E. Schlaffer, J. E. Russo, O. M. Colvin, C. I. Civin, and J. Hilton, “Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells,” Blood, vol. 75, no. 10, pp. 1947–1950, 1990.
- R. W. Storms, A. P. Trujillo, J. B. Springer et al., “Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 16, pp. 9118–9123, 1999.
- T. Gentry, S. Foster, L. Winstead, E. Deibert, M. Fiordalisi, and A. Balber, “Simultaneous isolation of human BM hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: implications for cell therapy,” Cytotherapy, vol. 9, no. 3, pp. 259–274, 2007.
- J. P. Chute, G. G. Muramoto, J. Whitesides et al., “Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 31, pp. 11707–11712, 2006.
- D. A. Hess, T. E. Meyerrose, L. Wirthlin et al., “Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity,” Blood, vol. 104, no. 6, pp. 1648–1655, 2004.
- R. W. Storms, P. D. Green, K. M. Safford et al., “Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34,” Blood, vol. 106, no. 1, pp. 95–102, 2005.
- D. A. Hess, L. Wirthlin, T. P. Craft et al., “Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells,” Blood, vol. 107, no. 5, pp. 2162–2169, 2006.
- D. J. Pearce and D. Bonnet, “The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells,” Experimental Hematology, vol. 35, no. 9, pp. 1437–1446, 2007.
- O. Christ, K. Lucke, S. Imren et al., “Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity,” Haematologica, vol. 92, no. 9, pp. 1165–1172, 2007.
- T. Gentry, E. Deibert, S. J. Foster, R. Haley, J. Kurtzberg, and A. E. Balber, “Isolation of early hematopoietic cells, including megakaryocyte progenitors, in the ALDH-bright cell population of cryopreserved, banked UC blood,” Cytotherapy, vol. 9, no. 6, pp. 569–576, 2007.
- P. Fallon, T. Gentry, A. E. Balber et al., “Mobilized peripheral blood SSCloALDHbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous transplantation,” British Journal of Haematology, vol. 122, no. 1, pp. 99–108, 2003.
- T. J. Povsic, K. L. Zavodni, F. L. Kelly et al., “Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity,” Journal of the American College of Cardiology, vol. 50, no. 23, pp. 2243–2248, 2007.
- M. Nagano, T. Yamashita, H. Hamada et al., “Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood,” Blood, vol. 110, no. 1, pp. 151–160, 2007.
- S. Corti, F. Locatelli, D. Papadimitriou et al., “Transplanted ALDHhiSSClo neural stem cells generate motor neurons and delay disease progression of nmd mice, an animal model of SMARD1,” Human Molecular Genetics, vol. 15, no. 2, pp. 167–187, 2006.
- S. Corti, M. Nizzardo, M. Nardini et al., “Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy,” Journal of Clinical Investigation, vol. 118, no. 10, pp. 3316–3330, 2008.
- K. Vauchez, J. P. Marolleau, M. Schmid et al., “Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacities,” Molecular Therapy, vol. 17, no. 11, pp. 1948–1958, 2009.
- E. Jean, D. Laoudj-Chenivesse, C. Notarnicola et al., “Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells,” Journal of Cellular and Molecular Medicine, vol. 15, no. 1, pp. 119–133, 2011.
- E. H. Huang, M. J. Hynes, T. Zhang et al., “Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis,” Cancer Research, vol. 69, no. 8, pp. 3382–3389, 2009.
- C. Ginestier, M. H. Hur, E. Charafe-Jauffret et al., “ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome,” Cell Stem Cell, vol. 1, no. 5, pp. 555–567, 2007.
- P. Marcato, C. A. Dean, D. Pan et al., “Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis,” Stem Cells, vol. 29, no. 1, pp. 32–45, 2011.
- C. S. Sondergaard, D. A. Hess, D. J. Maxwell et al., “Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction,” Journal of Translational Medicine, vol. 8, article 24, 2010.
- B. J. Capoccia, D. L. Robson, K. D. Levac et al., “Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity,” Blood, vol. 113, no. 21, pp. 5340–5351, 2009.
- G. I. Bell, H. C. Broughton, K. D. Levac, D. A. Allan, A. Xenocostas, and D. A. Hess, “Transplanted human bone marrow progenitor subtypes stimulate endogenous islet regeneration and revascularization,” Stem Cells and Development, vol. 21, no. 1, pp. 97–109, 2012.
- E. C. Perin, G. Silva, A. Gahremanpour et al., “A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia,” Catheterization and Cardiovascular Interventions, vol. 78, no. 7, pp. 1060–1067, 2011.
- E. C. Perin, G. V. Silva, Y. Zheng, et al., “First randomized, controlled double-blind trial of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells,” American Heart Journal, vol. 161, no. 6, pp. 1078–11087, 2011.
- E. C. Perin, G. V. Silva, Y. Zheng et al., “Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure,” American Heart Journal, vol. 163, no. 3, pp. 415–421, 2012.
- K. Urbanek, D. Cesselli, M. Rota et al., “Stem cell niches in the adult mouse heart,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 24, pp. 9226–9231, 2006.
- A. Meinhardt, A. Spicher, M. E. Roehrich, I. Glauche, P. Vogt, and G. Vassalli, “Immunohistochemical and flow cytometric analysis of long-term label-retaining cells in the adult heart,” Stem Cells and Development, vol. 20, no. 2, pp. 211–222, 2011.
- C. Castaldo, F. Di Meglio, D. Nurzynska et al., “CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and α6 integrin expression,” Stem Cells, vol. 26, no. 7, pp. 1723–1731, 2008.
- M. Baddoo, K. Hill, R. Wilkinson et al., “Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection,” Journal of Cellular Biochemistry, vol. 89, no. 6, pp. 1235–1249, 2003.
- H. Qian, K. Le Blanc, and M. Sigvardsson, “Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein,” The Journal of Biological Chemistry, vol. 287, no. 31, pp. 25795–25807, 2012.
- M. Al-Hajj, M. S. Wicha, A. Benito-Hernandez, S. J. Morrison, and M. F. Clarke, “Prospective identification of tumorigenic breast cancer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 3983–3988, 2003.
- C. Chen, Y. Wei, M. Hummel et al., “Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma,” PLoS ONE, vol. 6, no. 1, Article ID e16466, 2011.
- Y. Alnouti and C. D. Klaassen, “Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice,” Toxicological Sciences, vol. 101, no. 1, pp. 51–64, 2008.
- H. Storrie White, L. Smith, T. Gentry, and A. E. Balber, “Mechanisms of action of human aldehyde dehydrogenase bright cells in therapy of cardiovascular diseases: expression analysis of angiogenic factors and aldehyde dehydrogenase isozymes,” Journal of Stem Cell Research. In press, http://dx.doi.org/10.4172/2157-7633.S1-001.
- B. P. Levi, Ö. H. Yilmaz, G. Duester, and S. J. Morrison, “Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems,” Blood, vol. 113, no. 8, pp. 1670–1680, 2009.
- P. Marcato, C. A. Dean, C. A. Giacomantonio, and P. W. K. Lee, “Aldehyde dehydrogenase its role as a cancer stem cell marker comes down to the specific isoform,” Cell Cycle, vol. 10, no. 9, pp. 1378–1384, 2011.
- J. S. Moreb, H. V. Baker, L. J. Chang et al., “ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells,” Molecular Cancer, vol. 7, article 87, 2008.
- G. R. Budas, M. H. Disatnik, and D. Mochly-Rosen, “Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?” Trends in Cardiovascular Medicine, vol. 19, no. 5, pp. 158–164, 2009.
- J. I. Garaycoechea, G. P. Crossan, F. Langevin, M. Daly, M. J. Arends, and K. J. Patel, “Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function,” Nature, vol. 489, no. 7417, pp. 571–575, 2012.
- M. Nagano, K. Kimura, T. Yamashita et al., “Hypoxia responsive mesenchymal stem cells derived from human umbilical cord blood are effective for bone repair,” Stem Cells and Development, vol. 19, no. 8, pp. 1195–1210, 2010.
- E. Buchdunger, C. L. Cioffi, N. Law et al., “Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors,” Journal of Pharmacology and Experimental Therapeutics, vol. 295, no. 1, pp. 139–145, 2000.
- M. Crisan, S. Yap, L. Casteilla et al., “A perivascular origin for mesenchymal stem cells in multiple human organs,” Cell Stem Cell, vol. 3, no. 3, pp. 301–313, 2008.
- P. Campagnolo, D. Cesselli, A. Al Haj Zen et al., “Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential,” Circulation, vol. 121, no. 15, pp. 1735–1745, 2010.
- R. Katare, F. Riu, K. Mitchell et al., “Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132,” Circulation Research, vol. 109, no. 8, pp. 894–906, 2011.
- B. T. Estes, A. W. Wu, R. W. Storms, and F. Guilak, “Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells,” Journal of Cellular Physiology, vol. 209, no. 3, pp. 987–995, 2006.
- M. Petrini, S. Pacini, L. Trombi et al., “Identification and purification of mesodermal progenitor cells from human adult bone marrow,” Stem Cells and Development, vol. 18, no. 6, pp. 857–866, 2009.