Clinical Study

Heart Rate Variability Is Associated with Survival in Patients with Brain Metastasis: A Preliminary Report

Table 3

Prognostic factors for overall survival-univariate analysis and multivariate analysis.

CharacteristicsUnivariate analysisMultivariate analysis
3M survival (%)6M survival (%)Median survival (M) valueHR (95% CI) value

Gender0.711 0.604
 Female57.142.93.9 (—)
 Male47.435.52.0
Age0.283 0.303
 <6554.245.83.9 (—)
 ≥6550.029.22.6
Primary0.160 0.333
 NSCLC54.248.5 3.7(—)
 Others50.029.21.9
BM at diagnosis0.9960.775
 No50.036.72.3(—)
 Yes56.337.53.7
KPS0.0020.022
 <7031.30.631.9 2.657 (1.153–6.123)
 ≥7066.762.58.5Reference
Extracranial metastasis0.0870.171
 Without71.457.121.4(—)
 With48.536.42.6
Primary status0.4000.097
 Not controlled51.439.53.7 (—)
 Controlled60.040.03.9
SDNN (ms)0.004 0.039
 <1030.815.41.8 2.204 (1.046–4.733)
 ≥1063.051.48.0 Reference
RMSSD (ms)0.1000.868
 <742.9 21.4 1.9 (—)
 ≥757.7 49.75.7

HR: hazard ratio, CI: confidence interval, NSCLC: Nonsmall cell lung cancer, BM at Diagnosis: brain metastases confirmed at primary diagnosis, KPS: Karnofsky performance status, SDNN: standard deviation of normal-to-normal interval, and RMSSD: root mean square standard deviation of normal-to-normal interval.