Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Table 1

Livers of rats in the −ve control group showed normal histopathological appearance, where livers of rats treated with heavy metal mixtures that showed many histopathological changes are listed in the following table.

Figure	Histopathological change
(a)	Marked hepatic damage evidenced by foci of lobular necrosis with neutrophilic infiltration, adjacent to dysplastic hepatocytes, congested sinusoids, and frequent apoptotic nuclei
(b)	Marked large cell dysplasia of hepatocytes with focal necrosis and mild portal inflammatory infiltrate
(c)	Liver showing hydro pic changes in hepatocytes, and moderate portal lymphoplasmacytic infiltrate
(d)	Liver showing marked parenchymal hydro pic changes with apoptosis and adjacent regenerative hepatocytes with binucleated cells
(e)	Liver showing degenerative changes with frequent apoptotic cells at the same time evidence of beginning regeneration is seen with the appearance of binucleated cells
(f)	Section in the liver showing moderate portal lymphoplasmacytic infiltration with mild interface hepatitis. (H&E 400x)
(g)	Section in the liver showing intense heavy portal lymphoplasmacytic inflammatory infiltrate and dyspalstic changes of hepatocytes. (H&E 400x)
(h)	Liver showing coagulative necrosis and karyopickosis of the hepatocytes together with evidence of regeneration, multinucleated