- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 512086, 14 pages
Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues
Philip Morris International R&D, Philip Morris Products SA, Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland
Received 17 June 2013; Revised 14 August 2013; Accepted 16 August 2013
Academic Editor: Tao Huang
Copyright © 2013 Anita R. Iskandar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. J. Omiecinski, J. P. Vanden Heuvel, G. H. Perdew, and J. M. Peters, “Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities,” Toxicological Sciences, vol. 120, supplement 1, pp. S49–S75, 2011.
- A. Sharma, K. Saurabh, S. Yadav, S. K. Jain, and D. Parmar, “Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals,” International Journal of Hygiene and Environmental Health, 2012.
- S. S. Hecht, “DNA adduct formation from tobacco-specific N-nitrosamines,” Mutation Research, vol. 424, no. 1-2, pp. 127–142, 1999.
- D. Li, P. F. Firozi, L.-E. Wang et al., “Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis,” Cancer Research, vol. 61, no. 4, pp. 1445–1450, 2001.
- T. Shimada, “Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons,” Drug Metabolism and Pharmacokinetics, vol. 21, no. 4, pp. 257–276, 2006.
- N. M. DeVore and E. E. Scott, “Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes,” The Journal of Biological Chemistry, vol. 287, no. 32, pp. 26576–26585, 2012.
- J. Hukkanen, P. Jacob III, and N. L. Benowitz, “Metabolism and disposition kinetics of nicotine,” Pharmacological Reviews, vol. 57, no. 1, pp. 79–115, 2005.
- J. H. Kim, K. H. Stansbury, N. J. Walker, M. A. Trush, P. T. Strickland, and T. R. Sutter, “Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1,” Carcinogenesis, vol. 19, no. 10, pp. 1847–1853, 1999.
- R. Piipari, K. Savela, T. Nurminen, et al., “Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers,” International Journal of Cancer, vol. 86, no. 5, pp. 610–616, 2000.
- D. H. Phillips, B. Schoket, A. Hewer, E. Bailey, S. Kostic, and I. Vincze, “Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells,” International Journal of Cancer, vol. 46, no. 4, pp. 569–575, 1990.
- E. Croom, “Metabolism of xenobiotics of human environments,” Progress in Molecular Biology and Translational Science, vol. 112, pp. 31–88, 2012.
- Y. An, A. Kiang, J. P. Lopez et al., “Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side population,” PLoS ONE, vol. 7, no. 11, Article ID e47919, 2012.
- M. van der Deen, E. G. E. de Vries, H. Visserman et al., “Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells,” Journal of Biochemical and Molecular Toxicology, vol. 21, no. 5, pp. 243–251, 2007.
- X. Ding and L. S. Kaminsky, “Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts,” Annual Review of Pharmacology and Toxicology, vol. 43, no. 1, pp. 149–173, 2003.
- N. Finnström, B. Ask, M.-L. Dahl, M. Gadd, and A. Rane, “Intra-individual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes,” Pharmacogenomics Journal, vol. 2, no. 2, pp. 111–116, 2002.
- T. Thum, V. J. Erpenbeck, J. Moeller, J. M. Hohlfeld, N. Krug, and J. Borlak, “Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers,” Environmental Health Perspectives, vol. 114, no. 11, pp. 1655–1661, 2006.
- S. Sridhar, F. Schembri, J. Zeskind et al., “Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium,” BMC Genomics, vol. 9, article 259, 2008.
- X. Zhang, P. Sebastiani, G. Liu et al., “Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium,” Physiological Genomics, vol. 41, no. 1, pp. 1–8, 2010.
- A. Spira, J. Beane, V. Shah et al., “Effects of cigarette smoke on the human airway epithelial cell transcriptome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 27, pp. 10143–10148, 2004.
- J. Beane, P. Sebastiani, G. Liu, J. S. Brody, M. E. Lenburg, and A. Spira, “Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression,” Genome Biology, vol. 8, no. 9, article R201, 2007.
- K. Steiling, J. Ryan, J. S. Brody, and A. Spira, “The field of tissue injury in the lung and airway,” Cancer Prevention Research, vol. 1, no. 6, pp. 396–403, 2008.
- J. Hoeng, M. Talikka, F. Martin, et al., “Toxicopanomics: applications of genomics, transcriptomics, proteomics and lipidomics in predictive mechanistic toxicology,” in Principle and Methods on Toxicology, A. W. Hayes, Ed., Taylor & Francis, 2013.
- J. Hoeng, M. Talikka, F. Martin et al., “Case study: the role of mechanistic network models in systems toxicology,” Drug Discovery Today, 2013.
- Selventa, “Reverse Causal Reasoning Methods Whitepaper,” http://www.selventa.com/technology/white-papers.
- T. M. Thomson, A. Sewer, F. Martin et al., “Quantitative assessment of biological impact using transcriptomic data and mechanistic network models,” Toxicology and Applied Pharmacology, 2013.
- W. K. Schlage, J. W. Westra, S. Gebel et al., “A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue,” BMC Systems Biology, vol. 5, article 168, 2011.
- S. Gebel, R. B. Lichtner, B. Frushour et al., “Construction of a computable network model for DNA damage, autophagy, cell death, and senescence,” Bioinformatics and Biology Insights, vol. 7, pp. 97–117, 2013.
- J. W. Westra, W. K. Schlage, B. P. Frushour et al., “Construction of a computable cell proliferation network focused on non-diseased lung cells,” BMC Systems Biology, vol. 5, article 105, 2011.
- F. Martin, T. M. Thomson, A. Sewer et al., “Assessment of network perturbation amplitude by applying high-throughput data to causal biological networks,” BMC Systems Biology, vol. 6, no. 1, article 54, 2012.
- P. H. Karp, T. Moniger, S. P. Weber et al., “An in vitro model of differentiated human airway epithelia: methods for establishing primary cultures,” in Epithelial Cell Culture Protocols, C. Wise, Ed., vol. 188 of Methods in Molecular Medicine, chapter 11, pp. 115–137, 2002.
- C. Mathis, C. Poussin, D. Weisensee et al., “Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 304, no. 7, pp. L489–L503, 2013.
- H. Maunders, S. Patwardhan, J. Phillips, A. Clack, and A. Richter, “Human bronchial epithelial cell transcriptome: gene expression changes following acute exposure to whole cigarette smoke in vitro,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 292, no. 5, pp. L1248–L1256, 2007.
- A. A. Pezzulo, T. D. Starner, T. E. Scheetz et al., “The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 300, no. 1, pp. L25–L31, 2011.
- C. J. di Como, M. J. Urist, I. Babayan et al., “p63 expression profiles in human normal and tumor tissues,” Clinical Cancer Research, vol. 8, no. 2, pp. 494–501, 2002.
- J. L. McQualter, K. Yuen, B. Williams, and I. Bertoncello, “Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 4, pp. 1414–1419, 2010.
- S. Huang, L. Wiszniewski, and S. Constant, “The use of in vitro 3D cell models in drug development for respiratory diseases,” in Drug Discovery and Development—Present and Future, I. M. Kapetanovic, Ed., chapter 8, InTech, 2011.
- S. Parrinello, J.-P. Coppe, A. Krtolica, and J. Campisi, “Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation,” Journal of Cell Science, vol. 118, no. 3, pp. 485–496, 2005.
- Health Canada, “Determination of “tar”, nicotine, and carbon monoxide in mainstream tobacco smoke,” Official method T-115, 1999.
- R Development Core Team, R: A Language and Environment For Statistical Computing, 2009.
- R. Gentleman, Bioinformatics and Computational Biology Solutions Using R and Bioconductor, Springer Science, Business Media, New York, NY, USA, 2005.
- R. C. Gentleman, V. J. Carey, D. M. Bates et al., “Bioconductor: open software development for computational biology and bioinformatics,” Genome Biology, vol. 5, no. 10, article R80, 2004.
- R. A. Irizarry, B. Hobbs, F. Collin et al., “Exploration, normalization, and summaries of high density oligonucleotide array probe level data,” Biostatistics, vol. 4, no. 2, pp. 249–264, 2003.
- F. Martin, “Systems and methods for network-based biological activity assessment,” WO Patent 2,013,034,300, 2013.
- Y. Strulovici-Barel, L. Omberg, M. O'Mahony et al., “Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 12, pp. 1524–1532, 2010.
- F. Schembri, S. Sridhar, C. Perdomo et al., “MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 7, pp. 2319–2324, 2009.
- L. Stejskalova, L. Vecerova, L. M. Peréz et al., “Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures,” Toxicological Sciences, vol. 123, no. 1, pp. 26–36, 2011.
- Y. Bosse, D. S. Postma, D. D. Sin et al., “Molecular signature of smoking in human lung tissues,” Cancer Research, vol. 72, no. 15, pp. 3753–3763, 2012.
- S. Gebel, B. Gerstmayer, P. Kuhl, J. Borlak, K. Meurrens, and T. Müller, “The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression,” Toxicological Sciences, vol. 93, no. 2, pp. 422–431, 2006.
- J. O. Boyle, Z. H. Gümüş, A. Kacker et al., “Effects of cigarette smoke on the human oral mucosal transcriptome,” Cancer Prevention Research, vol. 3, no. 3, pp. 266–278, 2010.
- S. D. Spivack, G. J. Hurteau, R. Jain et al., “Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells,” Cancer Research, vol. 64, no. 18, pp. 6805–6813, 2004.
- D. Sidransky, “The oral cavity as a molecular mirror of lung carcinogenesis,” Cancer Prevention Research, vol. 1, no. 1, pp. 12–14, 2008.
- J. Dionísio, “Diagnostic flexible bronchoscopy and accessory techniques,” Revista Portuguesa de Pneumologia, vol. 18, no. 2, pp. 99–106, 2012.
- S. Anttila, J. Hakkola, P. Tuominen et al., “Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking,” Cancer Research, vol. 63, no. 24, pp. 8623–8628, 2003.
- V. Tamási, K. Monostory, R. A. Prough, and A. Falus, “Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s,” Cellular and Molecular Life Sciences, vol. 68, no. 7, pp. 1131–1146, 2011.
- D. H. Phillips, A. Hewer, C. N. Martin, R. C. Garner, and M. M. King, “Correlation of DNA adduct levels in human lung with cigarette smoking,” Nature, vol. 336, no. 6201, pp. 790–792, 1988.
- B. Schoket, D. H. Phillips, S. Kostic, and I. Vincze, “Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients,” Carcinogenesis, vol. 19, no. 5, pp. 841–846, 1998.
- L. Anna, K. Kovács, E. Gyorffy, B. Schoket, and J. Nair, “Smoking-related O4-ethylthymidine formation in human lung tissue and comparisons with bulky DNA adducts,” Mutagenesis, vol. 26, no. 4, pp. 523–527, 2011.
- E. Gyorffy, L. Anna, Z. Gyori et al., “DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking patients: correlations between tissues and detection by 32P-postlabelling and immunoassay,” Carcinogenesis, vol. 25, no. 7, pp. 1201–1209, 2004.
- M. Lodovici, V. Akpan, L. Giovannini, F. Migliani, and P. Dolara, “Benzo[a]pyrene diol-epoxide DNA adducts and levels of polycyclic aromatic hydrocarbons in autoptic samples from human lungs,” Chemico-Biological Interactions, vol. 116, no. 3, pp. 199–212, 1998.
- R. W. L. Godschalk, D. E. M. Feldker, P. J. A. Borm, E. F. M. Wouters, and F.-J. van Schooten, “Body mass index modulates aromatic DNA adduct levels and their persistence in smokers,” Cancer Epidemiology Biomarkers & Prevention, vol. 11, no. 8, pp. 790–793, 2002.
- A. Besaratinia, L. M. Maas, E. M. C. Brouwer, J. C. S. Kleinjans, and F. J. van Schooten, “Comparison between smoking-related DNA adduct analysis in induced sputum and peripheral blood lymphocytes,” Carcinogenesis, vol. 21, no. 7, pp. 1335–1340, 2000.
- S. Pavanello, A. Pulliero, B. O. Saia, and E. Clonfero, “Determinants of anti-benzo[a]pyrene diol epoxide-DNA adduct formation in lymphomonocytes of the general population,” Mutation Research, vol. 611, no. 1-2, pp. 54–63, 2006.