Table 1: Characteristics of studies included in the meta-analysis of the diagnosis of neonatal sepsis using a SAA test.

Study and yearStudy populationPatients ( )RegionAssay methodTime of SAA test: cutoff (mg/L)

Enguix et al. 2001 [31]Cases: NICU neonates with sepsis46SpainAMLNOnset: 41.3
Control: neonates without sepsis
Arnon et al. 2007 [21]Cases: full-term neonates with sepsis
Control: neonates without sepsis
104IsraelALPIAOnset: 8
24 h after the onset: 10
Çetinkaya et al. 2009 [29] Cases: NICU neonates with probable sepsis
Control: neonates without sepsis
163TurkeyINMMOnset: 68
48 h after the onset: 68
Yildiz et al. 2008 [23]Cases: NICU newborns with suspected sepsis
control: noninfected newborns
72TurkeyELISAOnset: 5.5
96 h after the onset: 5.7
Arnon et al. 2005 [22]Cases: neonates with proven or clinical sepsis
Control: noninfected newborns
116IsraelELISA Onset: 10
8 h after the onset: 10
Arnon et al. 2002 [44]Cases: preterm infants with sepsis or suspected sepsis
Control: healthy preterm infants
94IsraelELISAOnset: 10
Edgar et al. 2010 [24]Cases: term/preterm neonates with infection
Control: term/preterm neonates with infection
68EnglandELISAOnset: 1
Mostafa et al. 2011 [45]Cases: infants with sepsis or
suspected sepsis
Control: healthy neonates
100EgyptELISAOnset: >10
Mohsen et al. 2012 [30]Cases: term/preterm neonate with sepsis
Control: healthy neonates
60EgyptELISAOnset: cases, 40.16 ± 35.17
control, 6.45 ± 2.42

AMLN: automatic laser nephelometry; ALPIA: automated latex photometric immunoassay; INMM: immunonephelometric method; ELISA: enzyme-linked immunoassay; HSAIA: highly sensitive automated immunoassays, and NICU: neonatal intensive care unit.