- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 524165, 7 pages
Dose- and Time-Dependent Apoptosis Induced by Avian H9N2 Influenza Virus in Human Cells
Razi Vaccine & Serum Research Institute, P.O. Box 31975-148, Karaj 3197619751, Iran
Received 6 April 2013; Revised 17 July 2013; Accepted 12 August 2013
Academic Editor: Pranoti Mandrekar
Copyright © 2013 Shahla Shahsavandi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. M. Y. Lee, J. L. Gardy, C. Y. Cheung et al., “Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages,” PloS ONE, vol. 4, no. 12, Article ID e8072, 2009.
- V. S. Hinshaw, C. W. Olsen, N. Dybdahl-Sissoko, and D. Evans, “Apoptosis: a mechanism of cell killing by influenza A and B viruses,” Journal of Virology, vol. 68, no. 6, pp. 3667–3673, 1994.
- O. Haller, P. Staeheli, and G. Kochs, “Interferon-induced Mx proteins in antiviral host defense,” Biochimie, vol. 89, no. 6-7, pp. 812–818, 2007.
- O. Haller and G. Kochs, “Interferon-induced Mx proteins: dynamin-like GTPases with antiviral activity,” Traffic, vol. 3, no. 10, pp. 710–717, 2002.
- D. Holzinger, C. Jorns, S. Stertz et al., “Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling,” Journal of Virology, vol. 81, no. 14, pp. 7776–7785, 2007.
- M. Mibayashi, K. Nakade, and K. Nagata, “Promoted cell death of cells expressing human MxA by influenza virus infection,” Microbiology and Immunology, vol. 46, no. 1, pp. 29–36, 2002.
- T. Seyama, J. H. Ko, M. Ohe et al., “Population research of genetic polymorphism at amino acid position 631 in chicken Mx protein with differential antiviral activity,” Biochemical Genetics, vol. 44, pp. 432–433, 2006.
- R. J. Lowy, “Influenza virus induction of apoptosis by intrinsic and extrinsic mechanisms,” International Reviews of Immunology, vol. 22, no. 5-6, pp. 425–449, 2003.
- T. Ito, Y. Kobayashi, T. Morita, T. Horimoto, and Y. Kawaoka, “Virulent influenza A viruses induce apoptosis in chickens,” Virus Research, vol. 84, no. 1-2, pp. 27–35, 2002.
- S. J. Morris, G. E. Price, J. M. Barnett, S. A. Hiscox, H. Smith, and C. Sweet, “Role of neuraminidase in influenza virus-induced apoptosis,” Journal of General Virology, vol. 80, no. 1, pp. 137–146, 1999.
- S. Schultz-Cherry and V. S. Hinshaw, “Influenza virus neuraminidase activates latent transforming growth factor β,” Journal of Virology, vol. 70, no. 12, pp. 8624–8629, 1996.
- A. N. Chanturiya, “PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes,” Journal of Virology, vol. 78, no. 12, pp. 6304–6312, 2004.
- W. Chen, P. A. Calvo, D. Malide et al., “A novel influenza A virus mitochondrial protein that induces cell death,” Nature Medicine, vol. 7, no. 12, pp. 1306–1312, 2001.
- G. Kochs, A. García-Sastre, and L. Martínez-Sobrido, “Multiple anti-interferon actions of the influenza A virus NS1 protein,” Journal of Virology, vol. 81, no. 13, pp. 7011–7021, 2007.
- D. L. Noah, K. Y. Twu, and R. M. Krug, “Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS,” Virology, vol. 307, no. 2, pp. 386–395, 2003.
- O. P. Zhirnov, T. E. Konakova, T. Wolff, and H.-D. Klenk, “NS1 protein of influenza A virus down-regulates apoptosis,” Journal of Virology, vol. 76, no. 4, pp. 1617–1625, 2002.
- J. Talon, C. M. Horvath, R. Polley et al., “Activation of interferon regulatory factor 3 is inhibited by the influenza a virus NS1 protein,” Journal of Virology, vol. 74, no. 17, pp. 7989–7996, 2000.
- W. Y. Lam, A. C. M. Yeung, and P. K. S. Chan, “Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes,” Virology Journal, vol. 8, article 554, 2011.
- M. Shaw, L. Cooper, X. Xu et al., “Molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans,” Journal of Medical Virology, vol. 66, no. 1, pp. 107–114, 2002.
- T. Takizawa and Y. Nakanishi, “Role and pathological significance of apoptosis induced by influenza virus infection,” The Open Antimicrobiol Agents Journal, vol. 2, pp. 22–25, 2010.
- T. Daidoji, T. Koma, A. Du et al., “H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells,” Journal of Virology, vol. 82, no. 22, pp. 11294–11307, 2008.
- M. Uiprasertkul, R. Kitphati, P. Puthavathana et al., “Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans,” Emerging Infectious Diseases, vol. 13, no. 5, pp. 708–712, 2007.
- Z. Xing, R. Harper, J. Anunciacion et al., “Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 44, no. 1, pp. 24–33, 2010.
- Z. Xing, C. J. Cardona, S. Adams et al., “Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-mediated apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages,” Journal of General Virology, vol. 90, no. 5, pp. 1109–1118, 2009.
- S. Shahsavandi, A. Salmanian, S. A. Ghorashi, S. Masoudi, and M. M. Ebrahimi, “Evolutionary characterization of hemagglutinin gene of H9N2 influenza viruses isolated from Asia,” Research in Veterinary Science, vol. 93, pp. 234–239, 2012.
- S. Shahsavandi, M. M. Ebrahimi, A. Mohammadi, and N. Z. Lebas, “Impact of chicken-origin cells on adaptation of a low pathogenic influenza virus,” Cytotechnology, vol. 65, pp. 419–424, 2013.
- C. K. P. Mok, D. C. W. Lee, C. Cheung, M. Peiris, and A. S. Y. Lau, “Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages,” Journal of General Virology, vol. 88, no. 4, pp. 1275–1280, 2007.
- M. N. Matrosovich, T. Y. Matrosovich, T. Gray, N. A. Roberts, and H. Klenk, “Human and avian influenza viruses target different cell types in cultures of human airway epithelium,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 13, pp. 4620–4624, 2004.
- E. Böttcher, T. Matrosovich, M. Beyerle, H. Klenk, W. Garten, and M. Matrosovich, “Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium,” Journal of Virology, vol. 80, no. 19, pp. 9896–9898, 2006.
- N. Z. Lebas, S. Shahsavandi, A. Mohammadi, M. M. Ebrahimi, and M. Bakhshesh, “Replication efficiency of influenza virus H9N2: a comparative analysis between different origin cell types,” Jundishapur Microbiology Journal, vol. 86, no. 21, pp. 11725–11734, 2013.
- L. Ollier, A. Caramella, V. Giordanengo, and J. Lefebvre, “High permissivity of human HepG2 hepatoma cells for influenza viruses,” Journal of Clinical Microbiology, vol. 42, no. 12, pp. 5861–5865, 2004.
- Y. He, K. Xu, B. Keiner et al., “Influenza A virus replication induces cell cycle arrest in G0/G1 phase,” Journal of Virology, vol. 84, no. 24, pp. 12832–12840, 2010.
- W. Jiang, Q. Wang, S. Chen et al., “Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein,” Journal of Virology, vol. 87, pp. 3039–3052, 2013.
- O. P. Zhirnov and H. Klenk, “Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling,” Apoptosis, vol. 12, no. 8, pp. 1419–1432, 2007.
- M. Chen and J. Wang, “Initiator caspases in apoptosis signaling pathways,” Apoptosis, vol. 7, no. 4, pp. 313–319, 2002.
- W. C. Earnshaw, L. M. Martins, and S. H. Kaufmann, “Mammalian caspases: structure, activation, substrates, and functions during apoptosis,” Annual Review of Biochemistry, vol. 68, pp. 383–424, 1999.
- E. W. A. Brydon, S. J. Morris, and C. Sweet, “Role of apoptosis and cytokines in influenza virus morbidity,” FEMS Microbiology Reviews, vol. 29, no. 4, pp. 837–850, 2005.
- Z. T. Varga and P. Palese, “The influenza A virus protein PB1-F2: killing two birds with one stone?” Virulence, vol. 2, no. 6, pp. 542–546, 2011.
- R. V. Talanian, C. Quinlan, S. Trautz et al., “Substrate specificities of caspase family proteases,” The Journal of Biological Chemistry, vol. 272, no. 15, pp. 9677–9682, 1997.
- O. P. Zhirnov and V. V. Syrtzev, “Influenza virus pathogenicity is determined by caspase cleavage motifs located in viral proteins,” Journal of Molecular and Genetics Medicine, vol. 3, pp. 124–132, 2009.
- L. J. K. Wee, T. W. Tan, and S. Ranganathan, “SVM-based prediction of caspase substrates cleavage sites,” Bioinformatics, vol. 23, no. 23, pp. 3241–3243, 2007.