Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in <i>mdx</i> Mice

<table>Immunofluorescence analysis of intestinal smooth muscle of wild type (WT), untreated (<i>mdx</i>) and alginate-ZM2-M23D orally treated (Treated) <i>mdx</i> mice. The sections of small intestine were labeled with antidystrophin antibody. Serial sections of intestine were labeled with a polyclonal antibody for desmin (green). All samples were observed with a Nikon Eclipse 80i fluorescence microscope. Dystrophin (red) is clearly visible in the intestinal smooth muscle of WT mice, absent in untreated <i>mdx</i>, and rescued in treated <i>mdx</i> mice. (Scale bar = 50 <i>μ</i>m).</table>

BioMed Research International

fig4

Figure 4

Figure 4: Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in <i>mdx</i> Mice 

Figure 4 | Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice 