Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice

Table 1

Nanoparticles characteristics.

Sample	Diameter (SEM) nm (±standard error of the mean)	Diameter (PCS) nm (±polydispersity index)	Quaternary ammonium groups 𝜇mol/g	Primary amino groups 𝜇mol/g	NIPAM	Studies
ZM2	137±9	156±0.015	202	—	yes	Functional analysis (dystrophin rescue) with ZM2-AON and ZM2-AON alginate
ZM4	138±7	143±0.012	107	10.2	yes	Biodistribution and elimination using dye NIR-797