Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice
Table 2
Schedule of IR-dye conjugate nanoparticle treatments for biodistribution and elimination analysis.
No. ofmice
Oral formulations
Frequency
No. of administration
Time of analysis
ZM4-IR (2.5 mg)
1/week
1
Elimination (metabolic cages): 12 hours after administration Time of collection of Odyssey images: 12–24–48–72 hours
ZM4-IR (2.5 mg)
2/week
15
Time of collection of Odyssey images: before the new administration Sacrifice: 1 week, 1 month after last administration
