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BioMed Research International
/
2013
/
Article
/
Tab 3
/
Research Article
Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in
mdx
Mice
Table 3
Schedule of
mdx
treatments for dystrophin restoration studies.
Oral formulations
Frequency
No. of administrations
Total dose
Time of analysis
Group 1
Alginate-free
(
)
ZM2 (2.5 mg)-AON (225
g)
(
)
2/week
32
240 mg/Kg
1 week after last administration
ZM2 (2.5 mg)
(
)
2/week
32
—
1 week after last administration
Group II
Alginate-coated
(
)
ZM2 (2.5 mg)-AON (200
g)
(
)
3/week
36
240 mg/Kg
1 week after last administration
ZM2 (2.5 mg)
(
)
3/week
36
—
1 week after last administration
Group III
Untreated
(
)
—
—
—
—
1 week after last administration