Research Article
Expression of Multidrug Resistance-Associated Protein 2 in Human Gallbladder Carcinoma
Table 1
Relationship between the expression of MRP2 in GBCA and clinicopathological characteristics.
| Characteristics | Total | MRP2 expression | Positive (%) | Negative (%) | value |
| Age (year-old) | | | | | ≥64 | 71 | 42 (59.2) | 29 (40.8) |
0.153 | <64 | 72 | 34 (47.2) | 38 (52.8) | Sex | | | | | Man | 70 | 38 (54.3) | 32 (45.7) |
0.789 | Woman | 73 | 38 (52.1) | 35 (47.9) | Histologic grade | | | | | 1 (well differentiated) | 56 | 29 (51.8) | 27 (48.2) | | 2 (moderately differentiated) | 66 | 38 (57.6) | 28 (42.4) | 0.736 | 3 (poorly differentiated) | 21 | 9 (42.9) | 12 (57.1) | | Tumor size (cm) | | | | | ≥2.5 | 72 | 38 (52.8) | 34 (47.2) |
0.929 | <2.5 | 71 | 38 (53.5) | 33 (46.5) | Pathological T stage | | | | | pT1 | 23 | 9 (39.1) | 14 (60.9) | | pT2 | 80 | 47 (58.8) | 33 (41.3) |
0.743 | pT3 | 28 | 14 (50.0) | 14 (50.0) | pT4 | 12 | 6 (50.0) | 6 (50.0) | | Nodal metastasis | | | | | Present | 50 | 26 (52.0) | 24 (48.0) | | Absent | 83 | 47 (56.6) | 36 (43.4) | 0.604 | Unknown | 10 | | | | Distant metastasis | | | | | Present | 25 | 13 (52.0) | 12 (48.0) |
0.899 | Absent | 118 | 63 (53.4) | 55 (46.6) | TNM Stage | | | | | I | 17 | 6 (35.3) | 11 (64.7) | | II | 43 | 29 (52.4) | 14 (32.6) | | III | 63 | 33 (52.4) | 30 (47.6) | 0.868 | IV | 10 | 5 (50.0) | 5 (50.0) | | Unknown | 10 | | | | Local recurrence | | | | | Present | 25 | 18 (72.0) | 7 (28.0) |
0.038* | Absent | 118 | 58 (49.2) | 60 (50.8) | Lymphatic invasion | | | | | Present | 60 | 38 (63.3) | 22 (36.7) |
0.038* | Absent | 83 | 38 (45.8) | 45 (54.2) | Vascular invasion | | | | | Present | 36 | 25 (69.4) | 11 (30.6) |
0.023* | Absent | 107 | 51 (47.7) | 56 (52.3) | Perineural invasion | | | | | Present | 29 | 22 (75.9) | 7 (24.1) |
0.006* | Absent | 114 | 54 (47.4) | 60 (52.6) | Resection margin involvement | | | | | Present | 17 | 10 (58.8) | 7 (41.2) |
0.617 | Absent | 126 | 66 (52.4) | 60 (47.6) |
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Statistically significant.
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