Expression of Multidrug Resistance-Associated Protein 2 in Human Gallbladder Carcinoma

Table 2

Factors predicting worse outcome of patients with GBCA (univariate and multivariate survival analyses).

Characteristics	Univariate	Multivariate
	𝑃 value	HR (95% CI)	𝑃 value
Age (years old), ≥64 versus <64	0.920	Not applicable
Sex, man versus woman	0.067	1.582 (0.706–2.257)	0.187
Histological grade, 2/3 versus 1	0.001*	2.074 (1.196–3.596)	0.009*
Tumor size (cm), ≥2.5 versus <2.5	0.500	Not applicable
Pathological T stage, pT3/4 versus pT1/2	<0.001*	2.277 (1.279–4.054)	0.005*
Nodal metastasis, present versus absent	0.034*	0.740 (0.333–1.643)	0.460
Distant metastasis, present versus absent	0.028*	1.353 (0.732–2.500)	0.335
TNM stage, III/IV versus I/II	<0.001*	1.693 (0.912–3.140)	0.095
Local recurrence, present versus absent	<0.001*	4.595 (2.541–8.309)	<0.001*
Lymphatic invasion, present versus absent	<0.001*	1.063 (0.524–2.159)	0.866
Vascular invasion, present versus absent	0.005*	1.092 (0.620–1.924)	0.760
Perineural invasion, present versus absent	0.002*	1.162 (0.601–2.249)	0.655
Resection margin involvement, present versus absent	<0.013*	2.060 (1.026–4.133)	0.042*
MRP2 expression, positive versus negative	0.011*	1.473 (0.877–2.476)	0.143

∗Statistically significant.